PREVENTION OF VENTRICULAR FIBRILLATION BY USE OF LOW‐INTENSITY ELECTRICAL STIMULI *
PREVENTION OF VENTRICULAR FIBRILLATION BY USE OF LOW‐INTENSITY ELECTRICAL STIMULI *
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使用低强度电刺激预防心室颤动*
DOI：
10.1111/j.1749-6632.1982.tb55230.x
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发表时间：
1982
影响因子：
5.2
通讯作者：
B. Lown
中科院分区：
文献类型：
--
作者：
R. Verrier;B. Lown
Wiggers和Wegria的开创性研究早在40多年前就证明，在心脏周期的脆弱阶段，通过相对低能量的放电可以诱导心室颤动（VF）。事实上，在正常心脏中，小于1焦耳的经胸刺激就足以引起心室颤动然而，这种心律失常一旦发生，就需要数百倍的能量才能结束即使通过内部方法进行除颤，也需要相当大的能量，范围在20到30焦耳之间。大约9年前，Wolf等人在我们的实验室进行的研究发现，在心脏周期中有一段时间可以通过低强度的电刺激来预防心室颤动。这个区间被称为保护区（PZ），与脆弱期紧密相连。当一个刺激在保护区内传递时，纤维性颤动可以用小于1焦耳的能量来预防。本文的目的是回顾目前对保护区的了解，并提出未来的研究方向。
The pioneering studies of Wiggers and Wegria 1 demonstrated more than 40 years ago that ventricular fibrillation (VF) could be induced by delivering a relatively low-energy electrical discharge during the vulnerable phase of the cardiac cycle. Indeed, in the normal heart a transthoracic stimulus of less than 1 joule is sufficient to precipitate ventricular fibrillation.2 However, once this arrhythmia ensues, energies several hundred times as great are required for its termination.2 Even when defibrillation is carried out by internal means, considerable energy, ranging between 20 and 30 joules, is required.$ Studies conducted by Wolf er al.4 in our laboratory about 9 years ago led to the discovery of a period in the cardiac cycle during which ventricular fibrillation can be prevented by low-intensity electrical stimuli. This interval, designated the protective zone (PZ) , was found to closely adjoin the vulnerable period. When a stimulus is delivered during the protective zone, fibrillation can be prevented with less than 1 joule of energy. The objectives of this paper are to review what is currently known about the protective zone and to suggest directions for future research.