Activity of mupirocin and 14 additional antibiotics against staphylococci isolated from Latin American hospitals: Report from the SENTRY Antimicrobial Surveillance Program
Activity of mupirocin and 14 additional antibiotics against staphylococci isolated from Latin American hospitals: Report from the SENTRY Antimicrobial Surveillance Program
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DOI：
10.1179/joc.2004.16.4.323
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发表时间：
2004-08-01
影响因子：
1.8
通讯作者：
Jones, RN
中科院分区：
文献类型：
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作者：
Gales, AC;Andrade, SS;Jones, RN
作为SENTRY抗菌药物监测项目的一部分，采用参考肉汤微量稀释法对2000年至2001年间从11个拉丁美洲医疗中心分离的1346株金黄色葡萄球菌（SA）和498株凝固酶阴性葡萄球菌（con）菌株对莫匹罗星和其他抗菌药物的耐药性进行了检测。金黄色葡萄球菌对莫西林耐药（OR）的比例为38.6%，con为78.1%。金黄色葡萄球菌对莫西林的总体耐药率较低（3.1%，MIC大于等于8 mud/ml），但ORSA的耐药率明显高于对莫西林敏感的SA（5.4%对1.7%,p < 0.001）。11个中心中有9个中心检出耐莫匹罗星金黄色葡萄球菌，个别中心检出率在1.8 ~ 15.7%之间。莫匹罗星耐药率在con中较高（27.5%），在监测的拉丁美洲医疗中心之间差异很大（10.0% ~ 48.9%）。莫匹罗星耐药率似乎在增加，对潜在耐药性的常规监测似乎是谨慎的。
A total of 1,346 Staphylococcus aureus (SA) and 498 coagulase-negative staphylococcal (CoNS) strains isolated from 11 Latin American medical centers between 2000 and 2001 were tested against mupirocin and other antimicrobial agents by reference broth microdilution method as part of the SENTRY Antimicrobial Surveillance Program. Oxacillin resistance (OR) was detected in 38.6% of S. aureus and in 78.1% of CoNS. The overall resistance rate to mupirocin was low among S. aureus (3.1%; MIC greater than or equal to8 mud/ml) but significantly higher among ORSA compared to oxacillin-susceptible SA (5.4% versus 1.7%; p < 0.001). Mupirocin-resistant S. aureus strains were detected in 9 of 11 centers, with individual center rates varying between 1.8 and 15.7%. Mupirocin resistance rates were high among CoNS (27.5%) and varied widely (10.0 to 48.9%) among the monitored Latin American medical centers. Mupirocin resistance rates appear to be increasing and routine monitoring for potential resistance seems prudent.