The effects of spike frequency adaptation and negative feedback on the synchronization of neural oscillators
The effects of spike frequency adaptation and negative feedback on the synchronization of neural oscillators
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DOI：
10.1162/08997660152002861
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发表时间：
2001-06-01
影响因子：
2.9
通讯作者：
Gutkin, B
中科院分区：
文献类型：
--
作者：
Ermentrout, B;Pascal, M;Gutkin, B
在大脑皮层神经元的记录中观察到尖峰频率适应有几种不同的生物物理机制。模型研究中最常用的两种是钙依赖型钾电流I-AHP和慢电压依赖型钾电流I-m。我们发现这两种情况对兴奋性耦合神经元的同步特性都有很强的影响。此外，我们还表明，产生这些影响的原因是不同的。我们通过对一些标准模型的分析表明，M电流适应改变了重复放电的机制，而后超极化适应是通过分流传入突触来发挥作用的。后一种机制适用于具有反复抑制作用的网络。分流行为是在一个简单的双变量简化模型中捕捉到的，该模型出现在某些类型的分叉附近。从简化的模型导出一维地图。
There are several different biophysical mechanisms for spike frequency adaptation observed in recordings from cortical neurons. The two most commonly used in modeling studies are a calcium-dependent potassium current I-ahp and a slow voltage-dependent potassium current, I-m. We show that both of these have strong effects on the synchronization properties of excitatorily coupled neurons. Furthermore, we show that the reasons for these effects are different. We show through an analysis of some standard models, that the M-current adaptation alters the mechanism for repetitive firing, while the afterhyperpolarization adaptation works via shunting the incoming synapses. This latter mechanism applies with a network that has recurrent inhibition. The shunting behavior is captured in a simple two-variable reduced model that arises near certain types of bifurcations. A one-dimensional map is derived from the simplified model.