Bone cancer pain
Bone cancer pain
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DOI：
10.1002/cncr.11144
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发表时间：
2003-02-01
期刊：
影响因子：
6.2
通讯作者：
Mantyh, PW
中科院分区：
文献类型：
--
作者：
Clohisy, DR;Mantyh, PW
背景。骨癌疼痛很常见，患有这种疼痛的患者可能很难治疗。开发用于研究这种情况的实验模型对于增进对恶性疾病患者疼痛机制的理解至关重要。方法。研究了骨癌的小鼠模型。对肿瘤引起的骨质破坏的程度、疼痛以及周围和中枢神经系统的神经化学特征进行联合分析，以研究骨癌疼痛。通过放射线照片和组织形态计量学评估疾病引起的骨破坏。通过自发和引发的行为来评估疼痛，神经化学分析涉及痛觉过敏肽和神经化学标记物的免疫组织化学检测。结果。患有远端股骨肉瘤的小鼠表现出疼痛的行为和神经化学指标。恶性骨病引起的疼痛在神经化学上与炎症和神经性疼痛状态不同。实验证据表明，疾病引起的骨溶解和肿瘤本身都会导致疼痛的产生，并且存在神经系统的外周和中枢敏化。结论。恶性骨病会产生一种独特的疼痛状态，涉及神经系统的敏感性。骨组织内疼痛状态的主要贡献者是破骨细胞骨吸收和恶性疾病本身。 (C) 2003 年美国癌症协会。
BACKGROUND. Bone cancer pain is very common, and patients with this type of pain may be difficult to treat. Development of an experimental model for studying this condition is critical to advancing an understanding of the mechanisms that cause pain in patients with malignant disease.METHODS. A murine model of bone cancer was studied. Combined analysis of the extent Of tumor-induced bone destruction, pain, and neurochemical characterization of the peripheral and central nervous systems was performed to investigate bone cancer pain. Disease-induced bone destruction was assessed by radiographs and histomorphometry. Pain was assessed by spontaneous and elicited behaviors, and neurochemical analysis involved immunohistochemical detection of by hyperalgesic peptides and neurocheinical markers.RESULTS. Mice with distal femoral sarcomas exhibited behavioral and neurocheinical measures of pain. The pain condition created by malignant bone disease was distinct neurochemically from inflammatory and neuropathic pain states. Experimental evidence indicated that both disease-induced osteolysis and tumors themselves contributed to the generation of pain and that peripheral and central sensitization of the nervous system was present.CONCLUSIONS. Malignant bone disease creates a unique pain state that involves sensitization of the nervous system. Major contributors to the pain state within the bone tissue are osteoclastic bone resorption and the malignant disease itself. (C) 2003 American Cancer Society.