Meta-analysis of emotion recognition deficits in major depressive disorder.
Meta-analysis of emotion recognition deficits in major depressive disorder.
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主要抑郁症中情绪识别缺陷的荟萃分析。
DOI：
10.1017/s0033291714002591
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发表时间：
2015-04
影响因子：
6.9
通讯作者：
Munafò MR
中科院分区：
文献类型：
--
作者：
Dalili MN;Penton-Voak IS;Harmer CJ;Munafò MR
许多研究探讨了抑郁症和面部情绪识别（ER）之间的关联。然而，这些研究使用了各种范式和多个刺激集，使得比较困难。很少有研究试图确定任何影响的大小，以及研究是否有足够的动力来检测它。我们进行了一项荟萃分析，以综合抑郁症患者与对照组相比ER研究的结果。在PubMed和Web of Science中确定了2013年6月之前发表的包括抑郁和对照样本的ER研究。排除了使用示意性面孔的研究、神经影像学研究和药物治疗研究。对k = 22个独立样本的荟萃分析表明，情绪识别受损[k = 22，g =-0.16，95%置信区间（CI）-0.25至0.07，p < 0.001]。关键的是，在愤怒、厌恶、恐惧、快乐和惊讶（k = 7-22，g =-0.42 to-0.17，p < 0.08）中观察到了这一点，但在悲伤（k = 21，g =-0.09，95%CI-0.23 to +0.06，p = 0.23）中没有观察到这一点。研究水平特征似乎与观察到的效应无关。功效分析表明，需要约615例病例和615例对照的样本，在α水平为0.05时，以80%的功效检测这种关联。这些发现表明，抑郁症文献中报道的ER损伤存在于除悲伤之外的所有基本情绪中。然而，效应量很小，以前的研究也不够有力。
Many studies have explored associations between depression and facial emotion recognition (ER). However, these studies have used various paradigms and multiple stimulus sets, rendering comparisons difficult. Few studies have attempted to determine the magnitude of any effect and whether studies are properly powered to detect it. We conducted a meta-analysis to synthesize the findings across studies on ER in depressed individuals compared to controls. Studies of ER that included depressed and control samples and published before June 2013 were identified in PubMed and Web of Science. Studies using schematic faces, neuroimaging studies and drug treatment studies were excluded. Meta-analysis of k = 22 independent samples indicated impaired recognition of emotion [k = 22, g = −0.16, 95% confidence interval (CI) −0.25 to −0.07, p < 0.001]. Critically, this was observed for anger, disgust, fear, happiness and surprise (k's = 7–22, g's = −0.42 to −0.17, p's < 0.08), but not sadness (k = 21, g = −0.09, 95% CI −0.23 to +0.06, p = 0.23). Study-level characteristics did not appear to be associated with the observed effect. Power analysis indicated that a sample of approximately 615 cases and 615 controls would be required to detect this association with 80% power at an alpha level of 0.05. These findings suggest that the ER impairment reported in the depression literature exists across all basic emotions except sadness. The effect size, however, is small, and previous studies have been underpowered.