Genes associated with the G2m(23) immunoglobulin allotype regulate the IgG subclass responses to Haemophilus influenzae type b polysaccharide vaccine.
Genes associated with the G2m(23) immunoglobulin allotype regulate the IgG subclass responses to Haemophilus influenzae type b polysaccharide vaccine.
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与 G2m(23) 免疫球蛋白同种异型相关的基因调节对 b 型流感嗜血杆菌多糖疫苗的 IgG 亚类反应。
DOI：
10.1093/infdis/157.6.1142
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Shackelford,PG
中科院分区：
文献类型：
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作者：
Granoff,DM;Suarez,BK;Pandey,JP;Shackelford,PG
我们确定了与 G2m(23) 同种异型（IgG2 分子的遗传标记）相关的基因是否影响 b 型流感嗜血杆菌多糖疫苗的抗体反应的亚类组成。对 70 名白人成年人进行免疫后，总 IgG、IgG1 和 IgG2 抗体浓度的几何平均值 (GM) 比免疫前浓度增加约 10 倍。 G2m 阳性受试者与 G2m 阴性受试者的免疫后血清中总抗体、IgG 或 IgG1 抗体浓度的 GM 没有显着差异 (23)。 G2m(23) 呈阳性的成年人的 GM IgG2 浓度比阴性受试者高出三倍多 (P< .001)。还分析了 61 名接受 b 型多糖疫苗免疫的阿米什成年人的抗体反应。 G2m(23) 阳性的成年人对胶囊的 GM 血清 IgG2 反应高于阴性的成年人 (P< .01)。这些数据表明与 G2m(23) 基因座相关的基因调节 H 抗体反应的 IgG 亚类组成。乙型流感多糖疫苗。
We determined whether genes associated with the G2m(23) allotype, a genetic marker on IgG2 molecules, influence the subclass composition of the antibody response toHaemophilus influenzaetype b polysaccharide vaccine. After immunizing 70 white adults, the geometric means (GMs) of the total, IgG, IgG1, and IgG2 antibody concentrations increased ∼10-fold over preimmunization concentrations. There was no significant difference in the GMs of the total, IgG, or IgG1 antibody concentrations in postimmunization sera from subjects positive versus those negative for G2m(23). Adults positive for G2m(23) had a GM IgG2 concentration more than threefold higher than that of negative subjects (P< .001). The antibody responses of 61 Amish adults immunized with type b polysaccharide vaccine were also analyzed. Those adults positive for G2m(23) had a higher GM serum IgG2 response to capsule than did those who were negative (P< .01). These data indicate that genes associated with the G2m(23) locus regulate the IgG subclass composition of the antibody response toH. influenzaetype b polysaccharide vaccine.