The role of cholesterol metabolism in leukemia.
The role of cholesterol metabolism in leukemia.
复制标题
胆固醇代谢在白血病中的作用
DOI：
10.1097/bs9.0000000000000016
复制
发表时间：
2019-08
期刊：
影响因子：
--
通讯作者：
Zeng H
中科院分区：
文献类型：
--
作者：
Zhao L;Zhan H;Jiang X;Li Y;Zeng H
摘要 白血病是一种常见的血液系统恶性肿瘤，总体预后较差。需要新的疗法来改善白血病患者的预后。胆固醇代谢重编程是白血病的一个特征性改变。许多代谢相关基因和代谢物对于白血病的进展和耐药性至关重要。探索与胆固醇稳态相关的潜在治疗靶点是一个有前途的领域。这篇综述总结了胆固醇及其衍生的中间代谢物的功能，并讨论了针对白血病这种代谢脆弱性的潜在药物。
Abstract Leukemia is a common hematological malignancy with overall poor prognosis. Novel therapies are needed to improve the outcome of leukemia patients. Cholesterol metabolism reprogramming is a featured alteration in leukemia. Many metabolic-related genes and metabolites are essential to the progress and drug resistance of leukemia. Exploring potential therapeutical targets related to cholesterol homeostasis is a promising area. This review summarized the functions of cholesterol and its derived intermediate metabolites, and also discussed potential agents targeting this metabolic vulnerability in leukemia.
DOI：
10.3390/v3101815
发表时间：
2011-10
期刊：
Viruses
影响因子：
--
作者：
Edwards DC;McKinnon KM;Fenizia C;Jung KJ;Brady JN;Pise-Masison CA
通讯作者：
Pise-Masison CA