Simultaneous synthesis of thioesters and iron–sulfur clusters in water: two universal components of energy metabolism
Simultaneous synthesis of thioesters and iron–sulfur clusters in water: two universal components of energy metabolism
复制标题
在水中同时合成硫酯和铁硫簇：能量代谢的两个通用成分
DOI：
10.1039/d0cc04078a
复制
发表时间：
2020
影响因子：
4.9
通讯作者：
McGlynn, Shawn E.
中科院分区：
文献类型：
--
作者：
Sanden, Sebastian A.;Yi, Ruiqin;Hara, Masahiko;McGlynn, Shawn E.
硫代酯是有机合成和生物合成反应途径中的重要中间体。在这里，我们表明，硫代酯可以在硫代乙酸酯和硫醇之间的水相反应中合成。该反应可以耦合到硫化物与亚铁或三价铁之间的第二反应，其驱动反应向前。我们还表明，硫酯形成过程中释放的硫化物可用于合成肽结合的[Fe-S]簇，这像硫酯，是古老的代谢成分。总之，我们的研究结果揭示了高能量酯的形成和氧化还原化学之间的原始联系。
Thioesters are important intermediates in both synthetic organic and biosynthetic reaction pathways. Here we show that thioesters can be synthesized in an aqueous reaction between thioacetate and thiols. The reaction can be coupled to a second reaction between sulfide and either ferrous or ferric iron, which drives the reaction forward. We furthermore demonstrate that sulfide released during thioester formation can be used in the synthesis of peptide bound [Fe–S] clusters, which like thioesters, are ancient components of metabolism. Together our results reveal a primordial linkage between high-energy ester formation and redox chemistry.