Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice
Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice
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DOI：
10.1128/aac.49.1.438-440.2005
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发表时间：
2005-01-01
影响因子：
4.9
通讯作者：
Donskey, CJ
中科院分区：
文献类型：
--
作者：
Pultz, NJ;Stiefel, U;Donskey, CJ
我们研究了抗生素治疗对成年小鼠光滑念珠菌肠道定植的影响。皮下注射头孢曲松、哌拉西林-他唑巴坦、克林霉素和甲硝唑可促进粪便定植密度增加，而头孢吡肟、左氧氟沙星和氨曲南则无此作用。这些发现表明，抑制肠道厌氧菌的抗生素促进了光滑C的定植。
We examined the effect of antibiotic treatment on establishment of intestinal colonization by Candida glabrata in adult mice. Subcutaneous ceftriaxone, piperacillin-tazobactam, clindamycin, and metronidazole promoted increased density of stool colonization, whereas cefepime, levofloxacin, and aztreonam did not. These findings suggest that antibiotics that inhibit intestinal anaerobes promote C glabrata colonization.