NERVE-CELL DEGENERATION AND DEATH IN TRIGEMINAL GANGLION OF ADULT RAT FOLLOWING PERIPHERAL-NERVE TRANSECTION
NERVE-CELL DEGENERATION AND DEATH IN TRIGEMINAL GANGLION OF ADULT RAT FOLLOWING PERIPHERAL-NERVE TRANSECTION
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DOI：
10.1007/bf01217921
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发表时间：
1978-01-01
期刊：
影响因子：
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通讯作者：
ARVIDSSON, J
中科院分区：
文献类型：
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作者：
ALDSKOGIUS, H;ARVIDSSON, J
本文用光镜和电镜观察了正常大鼠和单侧眶下神经切断的成年大鼠三叉神经节。术后长时间存活后，对手术侧和非手术侧的神经节进行神经节细胞计数。术后3-70天观察手术侧神经节超微结构的变化。定量观察显示，手术侧神经节细胞大量丢失。超微结构观察显示，神经节细胞变性，神经纤维变性，卫星细胞和雪旺细胞吞噬。三叉神经周围支损伤后脑干三叉神经传入纤维的变性可能与三叉神经节细胞的逆行变性有关。
Trigeminal ganglia of normal rats and of adult rats subjected to unilateral transection of the infraorbital nerve were studied by light microscopy and EM. Counts of ganglion cells in ganglia on operated and unoperated sides were made following long postoperative survival times. The ultrastructural changes in ganglia of the operated side were studied from 3-70 days postoperatively. The quantitative observations showed that a considerable loss of ganglion cells takes place on the operated side. The ultrastructural observations demonstrated the occurrence of ganglion cell degeneration, nerve fiber degeneration and phagocytosis by satellite and Schwann cells. The degeneration of trigeminal afferents in the brain stem following lesions of peripheral trigeminal nerve branches is probably related to retrograde degeneration of trigeminal ganglion cells.