High plasma cholesteryl ester transfer protein levels may favour reduced incidence of cardiovascular events in men with low triglycerides
High plasma cholesteryl ester transfer protein levels may favour reduced incidence of cardiovascular events in men with low triglycerides
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DOI：
10.1093/eurheartj/ehm062
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发表时间：
2007-04-01
影响因子：
39.3
通讯作者：
Dullaart, Robin P. F.
中科院分区：
文献类型：
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作者：
Borggreve, Susanna E.;Hillege, Hans L.;Dullaart, Robin P. F.
目的在高甘油三酯受试者中，高胆固醇酯转运蛋白(CETP)浓度与心血管疾病(CVD)风险增加相关。在甘油三酯相对较低的人群中，我们确定了血浆CETP与心血管疾病发生率的关系。方法和结果在排除基线水平的心血管疾病、糖尿病和降脂药物使用后，对参与前瞻性研究的男性进行嵌套病例对照研究。对111名在随访期间发生心血管事件的男性和116名未患心血管疾病的对照组进行了血浆CETP测定。空腹总胆固醇(P<；0.001)和甘油三酯(P<；0.001)升高，高密度脂蛋白(HDLc)降低(P=0.001)，而CETP无明显变化(P=0.39)。COX比例风险回归分析显示，调整年龄和血脂因素后，血浆CETP水平越高，心血管疾病风险越低(危险比0.84；95%可信区间0.69~1.03，P=0.10)。伴有甘油三酯的患者血浆CETP水平低于对照组(P=0.05
Aims High cholesteryl ester transfer protein (CETP) concentrations are associated with increased risk of cardiovascular disease (CVD) in subjects with high triglycerides. We determined the relationship of plasma CETP with incident CVD in a population with relatively low triglycerides.Methods and results A nested case-control study was performed in men participating in the prospective PREVEND study, after exclusion of CVD, diabetes mellitus, and lipid-lowering drugs use at baseline. Plasma CETP was measured in 111 men who developed a cardiovascular event (cases) during follow-up and in 116 controls who remained free of CVD. Fasting total cholesterol (P < 0.001) and triglycerides (P < 0.001) were higher, HDL cholesterol was lower (P=0.001), but CETP was similar in cases and controls (P=0.39). Cox proportional hazards regression analysis showed that CVD risk tended to be lower with higher plasma CETP after adjustment for age and lipids (hazard ratio 0.84; 95% CI 0.69-1.03, P=0.10). Plasma CETP was lower in cases than in controls (P=0.05) with triglycerides