A prospective quality of life study of patients with oral or pharyngeal carcinoma treated with external beam irradiation with or without brachytherapy
A prospective quality of life study of patients with oral or pharyngeal carcinoma treated with external beam irradiation with or without brachytherapy
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DOI：
10.1016/s0964-1955(96)00069-3
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发表时间：
1997-05-01
期刊：
影响因子：
4.8
通讯作者：
Westin, T
中科院分区：
文献类型：
--
作者：
Hammerlid, E;Mercke, C;Westin, T
这项纵向生活质量（QL）研究的目的是研究口腔癌或口咽癌患者的肿瘤相关症状和治疗副作用，并确定增加局部照射剂量（近距离放射治疗）是否影响QL。在1年内重复使用欧洲癌症研究和治疗组织生活质量核心问卷（EORTC QLQ-C30）、肿瘤特异性头颈部问卷和医院焦虑和抑郁量表（HAD）。共有105例患者，累积缓解率为89%。大多数症状和问题在治疗开始后2或3个月达到高峰。营养和疼痛被认为是主要问题，多达19-40%的人报告精神痛苦。与仅接受外照射的患者相比，接受额外近距离放射治疗的患者没有报告QL问题（疼痛除外）的任何增加。当治疗方案中包括近距离放射治疗时，生活质量似乎不受局部照射剂量增加的影响。(C)1997 Elsevier Science Ltd.
The aim of this longitudinal quality of life (QL) study, was to study tumour-related symptoms and treatment side-effects of patients with oral or oropharyngeal cancer and to determine whether an increased local dose of irradiation (brachytherapy) affected QL. The European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30), a tumour-specific Head and Neck questionnaire and the Hospital Anxiety and Depression scale (HAD) were used repeatedly during 1 year. There were 105 patients, with a cumulative response rate of 89%. Most symptoms and problems were at their peak 2 or 3 months after the start of treatment. Nutrition and pain were found to be the major problems, and as many as 19-40% reported psychiatric distress. Patients having received additional brachytherapy did not report any increase in QL problems (except for pain) compared with those having had external radiation only. Quality of life does not seem to be affected by the increased irradiation local dose given when brachytherapy is included in the treatment regimen. (C) 1997 Elsevier Science Ltd.