Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer.
Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer.
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自噬和凋亡在非小细胞肺癌中的作用
DOI：
10.3390/ijms18020367
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发表时间：
2017-02-10
影响因子：
5.6
通讯作者：
Cho WC
中科院分区：
文献类型：
--
作者：
Liu G;Pei F;Yang F;Li L;Amin AD;Liu S;Buchan JR;Cho WC
非小细胞肺癌(NSCLC)占所有肺癌的85%，是全球癌症相关死亡的主要原因。NSCLC预后差，对放化疗耐药，需要进一步研究NSCLC的分子机制，开发新的更有效的治疗方法。在非小细胞肺癌的病理生理学中，自噬和细胞凋亡的过程在非小细胞肺癌的病理生理学中起着至关重要的作用，这些过程导致蛋白质和细胞器的降解或细胞在细胞应激时死亡。通过共同的信号通路，自噬和凋亡之间的密切相互作用使我们对非小细胞肺癌病理生理调控的理解变得更加复杂。自噬的凋亡效应存在争议，因为在非小细胞肺癌中既有抑制作用也有刺激作用的报道。此外，调节自噬和凋亡的蛋白质之间也存在相互干扰的现象。本文就NSCLC中自噬与细胞凋亡关系的最新研究进展作一综述，旨在为发现新的致病因素和开发新的癌症治疗方法提供一些启示。
Non-small-cell lung cancer (NSCLC) constitutes 85% of all lung cancers, and is the leading cause of cancer-related death worldwide. The poor prognosis and resistance to both radiation and chemotherapy warrant further investigation into the molecular mechanisms of NSCLC and the development of new, more efficacious therapeutics. The processes of autophagy and apoptosis, which induce degradation of proteins and organelles or cell death upon cellular stress, are crucial in the pathophysiology of NSCLC. The close interplay between autophagy and apoptosis through shared signaling pathways complicates our understanding of how NSCLC pathophysiology is regulated. The apoptotic effect of autophagy is controversial as both inhibitory and stimulatory effects have been reported in NSCLC. In addition, crosstalk of proteins regulating both autophagy and apoptosis exists. Here, we review the recent advances of the relationship between autophagy and apoptosis in NSCLC, aiming to provide few insights into the discovery of novel pathogenic factors and the development of new cancer therapeutics.