Viral interactions with host cell Rab GTPases.
Viral interactions with host cell Rab GTPases.
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DOI：
10.1080/21541248.2017.1346552
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发表时间：
2018-03-04
期刊：
影响因子：
--
通讯作者：
Spearman P
中科院分区：
文献类型：
--
作者：
Spearman P
病毒是专性细胞内寄生虫，利用细胞机制进行复制周期的许多方面。有包膜病毒通常依靠宿主囊泡运输机制将其结构蛋白和基因组引导至病毒复制、组装和出芽的位点。 Rab GTP 酶与感染人类的许多重要病毒病原体的复制有关。本综述总结了病毒-Rab 蛋白相互作用，特别关注 Rab 相关贩运途径对疱疹病毒和 HIV-1 生命周期晚期事件的作用。
Viruses are obligate intracellular parasites that utilize cellular machinery for many aspects of their replication cycles. Enveloped viruses generally rely upon host vesicular trafficking machinery to direct their structural proteins and genomes to sites of virus replication, assembly, and budding. Rab GTPases have been implicated in the replication of many important viral pathogens infecting humans. This review provides a summary of virus-Rab protein interactions, with a particular focus on the role of Rab-related trafficking pathways on late events in the lifecycle of herpesviruses and of HIV-1.