Cardiovascular reactivity to acute psychological stress following sleep deprivation.
Cardiovascular reactivity to acute psychological stress following sleep deprivation.
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DOI：
10.1097/psy.0b013e31822ff440
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发表时间：
2011-10
影响因子：
3.3
通讯作者：
Buysse DJ
中科院分区：
文献类型：
--
作者：
Franzen PL;Gianaros PJ;Marsland AL;Hall MH;Siegle GJ;Dahl RE;Buysse DJ
心理压力和睡眠障碍是非常普遍的，都涉及心血管疾病的病因。鉴于心理困扰和睡眠障碍（包括睡眠时间短）的共同发生，本研究探讨了这两个因素对血压反应性的综合影响，以急性精神挑战任务后，充分休息和睡眠剥夺的实验条件。参与者（n=20）是健康的年轻人，没有当前或过去的睡眠，精神病或重大医学疾病。采用受试者内交叉设计，我们研究了两种实验条件下的急性应激反应：在实验室中正常睡眠一晚和完全睡眠剥夺一晚。管理两个标准化的心理压力任务，Stroop颜色词命名干扰任务和语音任务，这是由一个前压力基线，然后由后压力恢复期。每个阶段持续10分钟，在每个阶段每2.5分钟收集一次血压记录。在压力和恢复期的平均血压反应进行了检查与混合效应的协方差分析，控制基线血压。睡眠剥夺和应激对收缩压的影响存在显著的交互作用（F2，82.7 = 4.05，p =0.02）。与正常睡眠条件相比，在言语任务期间以及在两个基线期间，睡眠剥夺条件下的收缩压较高。睡眠剥夺放大收缩压增加心理压力。睡眠不足可能会通过压力生理失调增加心血管风险。
Psychological stress and sleep disturbances are highly prevalent and are both implicated in the etiology of cardiovascular diseases. Given the common co-occurrence of psychological distress and sleep disturbances including short sleep duration, this study examined the combined effects of these two factors on blood pressure reactivity to acute mental challenge tasks following well-rested and sleep deprived experimental conditions. Participants (n=20) were healthy young adults free from current or past sleep, psychiatric, or major medical disorders. Using a within-subjects crossover design, we examined acute stress reactivity under two experimental conditions: following a night of normal sleep in the laboratory and following a night of total sleep deprivation. Two standardized psychological stress tasks were administered, a Stroop color-word naming interference task and a speech task, which were preceded by a pre-stress baseline and followed by a post-stress recovery period. Each period was 10 minutes in duration, and blood pressure recordings were collected every 2.5 minutes throughout each period. Mean blood pressure responses during the stress and recovery periods were examined with a mixed effects analysis of covariance, controlling for baseline blood pressure. There was a significant interaction between sleep deprivation and stress on systolic blood pressure (F2,82.7=4.05, p=0.02). Systolic blood pressure was higher in the sleep deprivation condition compared with the normal sleep condition during the speech task, as well as during two baseline periods. Sleep deprivation amplified systolic blood pressure increases to psychological stress. Sleep loss may increase cardiovascular risk by dysregulating stress physiology.