Diagnosis of histological gastritis based on the Kyoto classification of gastritis in Japanese subjects ? including evaluation of aging and sex difference of histological gastritis
Diagnosis of histological gastritis based on the Kyoto classification of gastritis in Japanese subjects ? including evaluation of aging and sex difference of histological gastritis
复制标题
根据日本受试者胃炎京都分类诊断组织学胃炎？
DOI：
10.1080/00365521.2021.2002927
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发表时间：
2021
影响因子：
1.9
通讯作者：
Takao Toshihiro
中科院分区：
文献类型：
--
作者：
Sumi Naoki;Haruma Ken;Kamada Tomoari;Suehiro Mitsuhiko;Manabe Noriaki;Akiyama Takashi;Shiotani Akiko;Yamanaka Yoshiyuki;Fujimoto Sohachi;Takao Toshihiro
目的建立京都胃炎分级标准，通过胃镜检查诊断幽门螺杆菌(H.Pylori)感染。我们研究了京都胃炎分类在h.日本人幽门螺杆菌感染和组织性胃炎。此外，还观察了胃炎的组织学表现。方法选择2010年至2018年在本院行胃十二指肠镜检查的5 61例患者，年龄20~79 。胃窦和胃体的内窥镜活检标本被用来研究H。幽门感染和组织学。结果胃镜检查结果对组织性胃炎诊断的敏感度和特异度分别为98.7%和98.4%。此外，三个年龄组(20-39岁、40-59岁和60-79岁 )的内窥镜检查结果具有较高的敏感性和特异性。肠上皮化生和萎缩仅见于H。幽门螺杆菌阳性组，且随年龄增长而增加。青年组幽门黏膜组织学炎症反应。幽门螺杆菌阳性患者显著高于老年组。结论京都胃炎分级不仅能诊断H。幽门螺杆菌感染还可检测出组织性胃炎。组织性胃炎具有不同的炎症、萎缩和肠化生的特征，这取决于年龄和性别。
ObjectivesThe Kyoto classification of gastritis was established for diagnosingHelicobacter pylori(H. pylori) infectionviaendoscopic findings. We investigated the role of the Kyoto classification of gastritis in the diagnosis ofH. pyloriinfection and histological gastritis in Japanese individuals. Moreover, the histological findings of gastritis inH. pyloriinfection were examined based on age and sex differences.MethodsWe selected 561 patients aged 20–79 years who underwent gastroduodenal endoscopy at our hospital between 2010 and 2018. Endoscopic biopsy specimens from the antrum and corpus were used to investigateH. pyloriinfection and histology. Endoscopic findings were based on the Kyoto classification of gastritis, and histological findings were based on the updated Sydney System.ResultsEndoscopic findings based on the Kyoto classification of gastritis (H. pyloripositive, 303 patients;H. pylorinegative, 258 patients, based on endoscopic findings) had 98.7% sensitivity and 98.4% specificity for histological gastritis. In addition, endoscopic findings in the three age groups (20–39, 40–59, and 60–79 years) had high sensitivity and specificity. Atrophy and intestinal metaplasia were found only in theH. pylori-positive group and progressed with age. Histological inflammation of pyloric mucosa in the younger age group ofH. pylori-positive patients was significantly higher than that in the elderly group. Significant inflammation was observed in young women.ConclusionsThe Kyoto classification of gastritis can not only diagnoseH. pyloriinfection but also detect histological gastritis. Histological gastritis has varying characteristics of inflammation, atrophy, and intestinal metaplasia, depending on age and sex.