Phylogenetic analysis of swine influenza viruses recently isolated in Korea
Phylogenetic analysis of swine influenza viruses recently isolated in Korea
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DOI：
10.1007/s11262-008-0251-z
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发表时间：
2008-10-01
期刊：
影响因子：
1.6
通讯作者：
Song, D. S.
中科院分区：
文献类型：
--
作者：
Lee, C. S.;Kang, B. K.;Song, D. S.
在2005年和2006年韩国爆发严重的呼吸道疾病期间，从猪中分离出几种甲型流感病毒亚型。它们包括一个经典的猪H1N1亚型，两个猪-人-禽三重重组H1 N2亚型，和一个猪-人-禽三重重组H3 N2亚型。在目前的研究中，首次进行了遗传表征，以确定这些最近分离株的可能来源。系统发生分析表明，所有最近韩国分离的H1N1、H1 N2和H3 N2流感病毒与来自美国的病毒密切相关。血清学和基因分析表明，韩国H1 N2病毒亚型是直接从美国引进的，而不是由韩国H1N1和H3 N2之间的重组产生的。我们认为，H1N1，H1 N2和H3 N2病毒亚型，从韩国猪群中分离出来，起源于北美，这些病毒目前正在韩国猪群中传播。
Several influenza A viral subtypes were isolated from pigs during a severe outbreak of respiratory disease in Korea during 2005 and 2006. They included a classical swine H1N1 subtype, two swine-human-avian triple-recombinant H1N2 subtypes, and a swine-human-avian triple-recombinant H3N2 subtype. In the current study, genetic characterization to determine the probable origin of these recent isolates was carried out for the first time. Phylogenetic analysis indicated that all the recent Korean isolates of H1N1, H1N2, and H3N2 influenza are closely related to viruses from the United States. Serologic and genetic analysis indicated that the Korean H1N2 viral subtypes were introduced directly from the United States, and did not arise from recombination between Korean H1N1 and H3N2. We suggest that the H1N1, H1N2, and H3N2 viral subtypes that were isolated from the Korean swine population originated in North America, and that these viruses are currently circulating in the Korean swine population.