SPATIAL-DISTRIBUTION OF [C-14]2-LABELED DEOXYGLUCOSE UPTAKE IN THE OLFACTORY BULBS OF RATS STIMULATED WITH 2 DIFFERENT ODORS
SPATIAL-DISTRIBUTION OF [C-14]2-LABELED DEOXYGLUCOSE UPTAKE IN THE OLFACTORY BULBS OF RATS STIMULATED WITH 2 DIFFERENT ODORS
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DOI：
10.1016/0006-8993(80)90563-6
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发表时间：
1980-01-01
期刊：
影响因子：
2.9
通讯作者：
HOLLEY, A
中科院分区：
文献类型：
--
作者：
JOURDAN, F;DUVEAU, A;HOLLEY, A
用放射自显影法研究了对照组和气味刺激组大鼠嗅球对[14 C]2-脱氧-D-葡萄糖（2-DG）的摄取。最高的2-DG-摄取的位点与单个肾小球非常准确地一致。其他延髓组织学层似乎远不受嗅觉刺激的代谢影响。在用2种不同气味刺激的2组动物中比较肾小球激活的映射。各组选择性肾小球2-DG摄取的模式相当相似。它们的区别在于高度标记的肾小球的数量和位置。少数肾小球在强烈而纯净的气味刺激下代谢高度活化。气味的质量和肾小球激活模式之间可能存在相关性，但必须用其他化合物来证实。
The uptake of [14C]2-deoxy-D-glucose (2-DG) was studied by autoradiography in the olfactory bulbs of control and odor-stimulated rats. The sites of highest 2-DG-uptake coincide very accurately with individual glomeruli. The other bulbar histological layers appear to be far less metabolically affected by the olfactory stimulation. The mapping of the glomerular activation was compared in 2 groups of animals stimulated with 2 different odors. The patterns of selective glomerular 2-DG-uptake are rather similar within each group. They differ from one group to the other by the number and localization of the highly labeled glomeruli. A few glomeruli are metabolically highly activated by a strong and pure odor stimulation. A correlation may occur between the quality of the odor and the pattern of glomerular activation but it has to be confirmed with other compounds.