Study of the interactions between proximal femur 3d bone shape, cartilage health, and biomechanics in patients with hip Osteoarthritis.
Study of the interactions between proximal femur 3d bone shape, cartilage health, and biomechanics in patients with hip Osteoarthritis.
复制标题
髋骨关节炎患者股骨近端 3d 骨形状、软骨健康和生物力学之间相互作用的研究。
DOI：
10.1002/jor.23649
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Majumdar,Sharmila
中科院分区：
文献类型：
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作者：
Pedoia,Valentina;Samaan,MichaelA;Inamdar,Gaurav;Gallo,MatthewC;Souza,RichardB;Majumdar,Sharmila
本研究采用定量MRI和步态分析研究髋骨关节炎（OA）患者股骨近端三维骨形态、软骨形态、软骨生化组成和关节生物力学之间的关系。80名受试者接受了单侧髋关节MR成像：通过基于体素的松弛测量提取T1ρ和T2松弛时间，并通过基于3D MRI统计形状建模评估骨形状。此外，对76名研究对象进行了3D步态分析。采用线性回归和统计参数映射分析形状、软骨病变存在、严重程度与软骨T1ρ和T2之间的关系。进行了一项特别分析，以调查生物力学和形状的关联。我们的研究结果显示，冠状面颈轴角较高（模式1较高，髋外翻）、股骨颈较粗、股骨头球形较小（模式5较高，手枪握把）的受试者髋臼和股骨软骨异常更严重，与人口统计学因素的相互作用不同。髋外翻的受试者也表现出T1ρ和T2的延长。手枪握握畸形患者髋内旋角度减小，髋外翻患者髋内收力矩和力矩冲量峰值增大。本研究的结果建立了三维股骨近端形状变化与髋关节退行性变标志物之间的明确关系-形态学，成分，以及对可能与人口统计学和生物力学相互作用的见解，表明基于3D MRI的骨形状可能是早期髋关节退行性变的有希望的生物标志物。©2017骨科研究学会。Wiley期刊公司出版。[J]中华骨科杂志，2018。
In this study quantitative MRI and gait analysis were used to investigate the relationships between proximal femur 3D bone shape, cartilage morphology, cartilage biochemical composition, and joint biomechanics in subject with hip Osteoarthritis (OA). Eighty subjects underwent unilateral hip MR‐imaging: T1ρ and T2 relaxation times were extracted through voxel based relaxometry and bone shape was assessed with 3D MRI‐based statistical shape modeling. In addition, 3D gait analysis was performed in seventy‐six of the studied subjects. Associations between shape, cartilage lesion presence, severity, and cartilage T1ρ and T2 were analyzed with linear regression and statistical parametric mapping. An ad hoc analysis was performed to investigate biomechanics and shape associations. Our results showed that subjects with a higher neck shaft angle in the coronal plane (higher mode 1, coxa valga), thicker femoral neck and a less spherical femoral head (higher mode 5, pistol grip) exhibited more severe acetabular and femoral cartilage abnormalities, showing different interactions with demographics factors. Subjects with coxa valga also demonstrated a prolongation of T1ρ and T2. Subjects with pistol grip deformity exhibited reduced hip internal rotation angles and subjects with coxa valga exhibited higher peak hip adduction moment and moment impulse. The results of this study establish a clear relationship between 3D proximal femur shape variations and markers of hip joint degeneration—morphological, compositional, well as insight on the possible interactions with demographics and biomechanics, suggesting that 3D MRI‐based bone shape maybe a promising biomarker of early hip joint degeneration. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:330–341, 2018.