Ethnicity and survival in childhood acute myeloid leukemia: a report from the Children's Oncology Group
Ethnicity and survival in childhood acute myeloid leukemia: a report from the Children's Oncology Group
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DOI：
10.1182/blood-2005-10-4004
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发表时间：
2006-07-01
期刊：
影响因子：
20.3
通讯作者：
Davies, SM
中科院分区：
文献类型：
--
作者：
Aplenc, R;Alonzo, TA;Davies, SM
我们评估了急性髓系白血病 (AML) 儿童不同种族的结局差异。我们分析了 CCG 2891 试验中的 791 名儿童，并证实了 CCG 2961 试验中 850 名儿童的阳性结果。与白人儿童相比，在 CCG 2891 中接受化疗的西班牙裔和黑人儿童的总生存期 (OS) 显着较差（分别为 37% +/- 9% vs 48% +/- 4% [P=.016] 和 34% +/- 10% vs 48% +/- 4%，[P =.007]）。有亲属捐赠者的黑人儿童明显减少。 CCG 2961 的分析证实，与白人儿童相比，黑人儿童的 OS 率显着降低（45% +/- 12% vs 60% +/- 4%；P=.007）西班牙裔和白人儿童之间的 OS 率差异接近统计显着性（51% +/- 8% vs 60% +/- 4%；P=.065）CCG 2961 中只有 7.5% 的黑人儿童有可用的家庭捐赠者。总之，患有 AML 的西班牙裔和黑人儿童的生存率比白人儿童差。接受化疗、支持治疗或白血病表型的差异以及依从性降低不太可能解释这种差异，因为治疗是根据 CCG 方案静脉注射的。拥有可用家族骨髓捐赠者的黑人儿童数量比预期要少。
We evaluated differences in outcome by ethnicity among children with acute myeloid leukemia (AML). We analyzed 791 children in the CCG 2891 trial and confirmed positive findings in 850 children in the CCG 2961 trial. Hispanic and black children treated with chemotherapy in CCG 2891 had significantly inferior overall survival (OS) from study entry compared with white children (37% +/- 9% vs 48% +/- 4% [P=.016] and 34% +/- 10% vs 48% +/- 4%, [P =.007], respectively). Significantly fewer black children had related donors. Analyses of CCG 2961 confirmed that black children had significantly decreased OS rates compared with white children (45% +/- 12% vs 60% +/- 4%; P=.007) The difference in OS rates between Hispanic and white children approached statistical significance (51% +/- 8% vs 60% +/- 4%; P=.065) Only 7.5% of black children on CCG 2961 had an available family donor. In conclusion, Hispanic and black children with AML have worse survival than white children. Access to chemotherapy, differences in supportive care or leukemia phenotype, and reduced compliance are unlikely explanations for this difference because therapy was given intravenously according to CCG protocols. Fewer black children than expected had an available family marrow donor.