High concentrations of plasma immunoreactive inhibin during normal pregnancy in women.
High concentrations of plasma immunoreactive inhibin during normal pregnancy in women.
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女性正常妊娠期间血浆免疫反应性抑制素浓度较高。
DOI：
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发表时间：
1990
影响因子：
5.8
通讯作者：
M. Igarashi
中科院分区：
文献类型：
--
作者：
Y. Abe;Y. Hasegawa;K. Miyamoto;M. Yamaguchi;A. Andoh;Y. Ibuki;M. Igarashi
应用人抑制素特异性RIA测定了190例妊娠5 ~ 40周的正常孕妇和4例产褥期妇女的血浆抑制素浓度。孕妇在整个妊娠期间的平均血浆抑制素浓度（最低，妊娠17周时为2.25 +/- 0.48 IU/mL；最高，妊娠39周时为24.15 +/- 6.99 IU/mL）远高于月经周期正常的非孕妇（卵泡中期为0.46 +/- 0.04 IU/mL，黄体中期为2.02 +/- 0.47 IU/mL）。抑制素浓度在妊娠5周时已经很高（7.54 +/- 1.10 IU/mL），在妊娠8-10周时达到峰值。在妊娠14-30周期间浓度下降并保持相对较低，但在妊娠晚期再次上升。分娩后抑制素浓度下降到检测不到的水平。在黄体和足月胎盘提取物中证实了免疫反应性抑制素，其剂量-反应曲线与从人卵泡液中提取的抑制素制剂相似。免疫反应性抑制素在脐静脉和动脉中的浓度也很高（分别为7.77 +/- 0.80和7.84 +/- 0.78 IU/mL）。这些观察结果表明黄体和胎盘都可能是抑制素的来源。
The plasma inhibin concentrations in 190 normal pregnant women at 5-40 weeks gestation and in 4 puerperal women were measured by a specific RIA for human inhibin. The average plasma inhibin concentrations in pregnant women throughout pregnancy (minimum, 2.25 +/- 0.48 IU/mL at 17 weeks gestation; maximum, 24.15 +/- 6.99 IU/mL at 39 weeks gestation) were much higher than those in nonpregnant women with a normal menstrual cycle (0.46 +/- 0.04 IU/mL in the midfollicular phase and 2.02 +/- 0.47 IU/mL in the midluteal phase). The inhibin concentrations were already high at 5 weeks gestation (7.54 +/- 1.10 IU/mL) and rose to peak at 8-10 weeks gestation. The concentrations then decreased and remained relatively low during 14-30 weeks gestation, but rose again during the third trimester. The inhibin concentrations decreased to undetectable levels after delivery. Immunoreactive inhibin was demonstrated in the corpus luteum and term placental extracts, and the dose-response curves were parallel to an inhibin preparation from human follicular fluid. Immunoreactive inhibin concentrations were also high in both the umbilical vein and artery (7.77 +/- 0.80 and 7.84 +/- 0.78 IU/mL, respectively). These observations suggest that both the corpus luteum and placenta are likely sources of inhibin.
猪卵泡液中抑制素的纯化和部分表征。
DOI：
10.1016/0006-291x(85)91849-2
发表时间：
1985
影响因子：
3.1
作者：
Rivier,J;Spiess,J;McClintock,R;Vaughan,J;Vale,W
通讯作者：
Vale,W