ASSESSING SEQUENTIAL ONCOGENE AMPLIFICATION IN HUMAN BREAST-CANCER
ASSESSING SEQUENTIAL ONCOGENE AMPLIFICATION IN HUMAN BREAST-CANCER
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DOI：
10.1002/cyto.990210106
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发表时间：
1995-09-01
期刊：
影响因子：
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通讯作者：
SHACKNEY, SE
中科院分区：
文献类型：
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作者：
JANOCKO, LE;LUCKE, JF;SHACKNEY, SE
乳腺癌中c-myc、HER-2/neu和H-ras的扩增和/或过表达的研究表明，每一种都与不良预后相关。本研究对84例乳腺癌组织中c-myc、HER-2/neu和H-ras基因的扩增频率和共扩增模式进行了研究，结果表明：c-myc扩增-HER-2/neu扩增-H-ras扩增是乳腺癌组织中c-myc、HER-2/neu和H-ras基因扩增的优先顺序，此外，对其中61例晚期乳腺癌患者新分离的DNA片段JC-A的扩增水平进行了研究，结果表明JC-A扩增发生较早。对数线性分析支持一个模型，其中JC-A扩增发生在c-myc扩增之前或之后，但与Her-2/neu或ras扩增无关。(C)1995年Wiley-Liss，Inc.
Studies of amplification and/or overexpression of c-myc, HER-2/neu, and H-ras in breast cancer have shown that each is associated with a poor prognosis. The purpose of this study was to explore the possibility that there is a preferred sequence of amplification of these oncogenes in breast cancer, The frequencies of amplification and patterns of co-amplification of c-myc, HER-2/neu, and H-ras were studied in a group of 84 breast cancers, The data suggested a preferred sequence of amplification that consisted of c-myc amplification-HER-2/neu amplification-H-ras amplification, This model was supported by loglinear analysis, In addition, the levels of amplification of JC-A, a DNA fragment newly isolated from a patient with advanced breast cancer, were studied in 61 of these cases, The data suggested that JC-A amplification occurred early. Loglinear analysis supported a model in which JC-A amplification occurred either before or after c-myc amplification but was unrelated to Her-2/neu or ras amplification. (C) 1995 Wiley-Liss, Inc.