Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls
Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls
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DOI：
10.1038/eye.2008.47
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发表时间：
2009-03-01
期刊：
影响因子：
3.9
通讯作者：
Zinkernagel, M. S.
中科院分区：
文献类型：
--
作者：
Ebneter, A.;Wagels, B.;Zinkernagel, M. S.
目的 体内确定药物引起的眼内压 (IOP) 变化是否会导致眼轴长度发生可测量的变化，以及青光眼患者和对照受试者之间是否存在差异。 方法 42 名受试者（19 名原发性开角型青光眼患者和 23 名年龄和性别匹配的对照患者）在口服 500 mg 之前和之后 2 小时，使用部分相干激光干涉仪进行眼轴长度测量，并使用动态轮廓眼压计测量 IOP乙酰唑酰胺。使用学生 t 检验来比较平均值的差异。 结果 青光眼组（平均值 +/- SEM：2.90 +/- 0.44 mmHg，n = 19）和对照组（平均值 +/- SEM：3.17 +/- 0.32 mmHg，n = 23）均引起相同的 IOP 下降。与对照组（平均值+/-SEM：-23.0+/-2.98μm，n = 23）相比，青光眼组（平均值+/-SEM：-14.2+/-3.2μm，n = 19）眼轴长度的变化显着较小（P = 0.026）。结论我们的结果强烈表明，与对照组相比，已确诊青光眼的患者眼部硬度增加。眼强直可能在青光眼的发病机制和病理生理学中发挥作用。眼硬度的测定有助于青光眼的检测。
Purpose To determine in vivo whether a pharmacologically induced change in intraocular pressure (IOP) leads to measurable changes in axial eye length and whether there is a difference between glaucoma patients and control subjects.Methods 42 subjects (19 patients with primary open angle glaucoma and 23 control patients matched for age and gender) underwent axial eye length measurement using partial coherence laser interferometry and measurement of IOP using dynamic contour tonometry before and 2 h after oral intake of 500 mg acetazolamide. Student's t-test was used to compare differences in the means.Results An identical drop in IOP was induced in both the glaucoma (mean +/- SEM: 2.90 +/- 0.44 mmHg, n = 19) and the control group (mean +/- SEM: 3.17 +/- 0.32 mmHg, n = 23). The change in axial eye length was significantly smaller (P = 0.026) in the glaucoma group (mean +/- SEM: -14.2 +/- 3.2 mu m, n = 19) compared with the control group (mean +/- SEM: -23.0 +/- 2.98 mu m, n = 23).Conclusions Our results strongly suggest that the ocular rigidity is increased in patients with established glaucoma in comparison to control subjects. Ocular rigidity could play a role in the pathogenesis and pathophysiology of glaucoma. Determination of ocular rigidity could be helpful in detection of glaucoma.