Hypothalamic stimulation and baroceptor reflex interaction on renal nerve activity.
Hypothalamic stimulation and baroceptor reflex interaction on renal nerve activity.
复制标题
下丘脑刺激和压力感受器反射对肾神经活动的相互作用。
作者：
M. Wilson;I. Ninomiya;G. N. Franz;W. Judy
在麻醉猫中测量的平均肾神经活动（mRNA-0）的基础水平被发现修改的下丘脑和压力感受器反射的影响的添加剂的相互作用。数据收集与四个主要的压力感受器神经完整或切断，和平均主动脉压（MAP）夹在水库或提高与l-肾上腺素。对于完整的压力感受器神经，对于低于初始压力P1的MAP，mRNA基本上保持恒定在mRNA-0水平，并且当MAP升高到P2时，mRNA近似线性地下降到零。切断压力感受器神经使mRNA保持在mRNA-0（假设代表基础中枢神经输出），不依赖于MAP。增加下丘脑刺激产生几乎恒定的增量mRNA的所有压力水平P2，完全抑制在一定程度上高于P2。mRNA的增量依赖于刺激的频率和位置。分段线性模型将mRNA描述为下丘脑、基底中枢神经和压力感受器反射活动的线性组合。
The basal level of mean renal nerve activity (MRNA-0) measured in anesthetized cats was found to be modified by the additive interaction of hypothalamic and baroceptor reflex influences. Data were collected with the four major baroceptor nerves either intact or cut, and with mean aortic pressure (MAP) either clamped with a reservoir or raised with l-epinephrine. With intact baroceptor nerves, MRNA stayed essentially constant at level MRNA-0 for MAP below an initial pressure P1, and fell approximately linearly to zero as MAP was raised to P2. Cutting the baroceptor nerves kept MRNA at MRNA-0 (assumed to represent basal central neural output) independent of MAP. The addition of hypothalamic stimulation produced nearly constant increments in MRNA for all pressure levels up to P2, with complete inhibition at some level above P2. The increments in MRNA depended on frequency and location of the stimulus. A piecewise linear model describes MRNA as a linear combination of hypothalamic, basal central neural, and baroceptor reflex activity.