A hydrophobic transmembrane segment at the carboxyl terminus of thy-1.
A hydrophobic transmembrane segment at the carboxyl terminus of thy-1.
复制标题
DOI：
10.1126/science.2857501
复制
发表时间：
1985-02
期刊：
影响因子：
56.9
通讯作者：
T. Seki;H. Chang;T. Moriuchi;R. Denome;H. Ploegh;J. Silver
中科院分区：
文献类型：
--
作者：
T. Seki;H. Chang;T. Moriuchi;R. Denome;H. Ploegh;J. Silver
The mode of integration of the glycoprotein thy-1 within the cell membrane has been controversial due to an apparent lack of a transmembrane hydrophobic segment. Rat and mouse complementary DNA and genomic clones encoding the thy-1 molecule have been isolated and sequenced. These studies have enabled us to determine the intron-exon organization of the thy-1 gene. Furthermore, they have revealed the existence of a sequence which would encode an extra segment (31 amino acids) at the carboxyl terminus of the thy-1 molecule. These extra amino acids include a 20-amino acid hydrophobic segment which may be responsible for integration of thy-1 within the plasma membrane.
