An immunohistochemical study of the bone marrow lesions of systemic mastocytosis - Expression of stem cell factor by lesional mast cells
An immunohistochemical study of the bone marrow lesions of systemic mastocytosis - Expression of stem cell factor by lesional mast cells
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DOI：
10.1309/71kh-4je4-e0j1-7thh
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发表时间：
2002-08-01
影响因子：
3.5
通讯作者：
Metcalfe, DD
中科院分区：
文献类型：
--
作者：
Akin, C;Jaffe, ES;Metcalfe, DD
肥大细胞增多症的骨髓活检常显示与淋巴样细胞聚集相关的特征性肥大细胞聚集。关于这些聚集体的组成以及它们是否含有对肥大细胞生长和发育重要的细胞因子的信息有限。因此，我们进行了免疫组化表征骨髓病变的7例系统性惰性肥大细胞增多症。在结节性病变中，肥大细胞的集合被淋巴聚集体包围;这些聚集体由B细胞和T细胞的混合物组成。干细胞因子（SCF）的免疫组化染色显示，这种细胞因子的存在下，在病变肥大细胞的颗粒染色模式。这些结果表明，在肥大细胞增多症患者的骨髓活检标本中观察到的特征性结节性病变具有良性淋巴聚集体的特征，SCF存在于这些病变中，为肥大细胞和淋巴祖细胞创造了潜在的自分泌或旁分泌生长和分化回路。
The bone marrow biopsy in mastocytosis often reveals characteristic mast cell collections associated with lymphoid cell aggregates. There is limited information on the composition of these aggregates and whether they, contain cytokines important to mast cell growth and development. We thus performed an immunohistochemical characterization of bone marrow lesions in 7 patients with systemic indolent mastocytosis. In nodular lesions, the collections of mast cells were surrounded by lymphoid aggregates; these aggregates consisted of a mixture of B and T cells. Immunohistochemical staining for stem cell factor (SCF) revealed the presence of this cytokine in the lesional mast cells with a granular staining pattern. These results show that the characteristic nodular lesions observed in bone marrow biopsy specimens of patients with mastocytosis bear features of benign lymphoid aggregates and that SCF is present in these lesions, creating a potential autocrine or paracrine growth and differentiation loop for mast cells and lymphoid progenitors.