Normal glucagon response to arginine infusion in "prediabetic" Pima Indians.
Normal glucagon response to arginine infusion in "prediabetic" Pima Indians.
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“糖尿病前期”皮马印第安人对精氨酸输注的正常胰高血糖素反应。
DOI：
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发表时间：
1976
影响因子：
5.8
通讯作者：
R. Unger
中科院分区：
文献类型：
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作者：
S. Aronoff;P. Bennett;N. Rushforth;M. Miller;R. Unger
为了确定胰高血糖素分泌异常是否可能先于糖尿病高血糖症的发作，32名糖尿病前期皮马（美洲）印第安人，27名正常皮马印第安人和34名正常高加索人接受了精氨酸单氯化物（5 mg/kg/min，持续40分钟）的输注，并测量葡萄糖、胰岛素和胰高血糖素。[糖尿病前期是概念和糖尿病发展之间的时期。在大多数研究中，该术语用于描述基于遗传原因被认为具有高风险发展疾病的患者，包括糖尿病患者的正常血糖单卵双胞胎或两个糖尿病父母的正常血糖后代。在本研究中使用后一种定义，认识到在最终分析中，真正的前驱糖尿病只能在糖尿病发展后的回顾中确定。三组的平均空腹胰高血糖素水平相似。在精氨酸输注过程中，糖尿病前期印度人达到平均最大胰高血糖素水平315 +/- 14 pg/ml（平均值+/- 1 SEM），而正常印度人为294 +/- 20 pg/ml，正常高加索人为292 +/- 25 pg/ml。糖尿病前期患者胰高血糖素曲线下高于基线的平均面积计算值为5704 +/- 324 pg/min/ml，正常印度人为5189 +/- 446 pg/min/ml，正常高加索人为4239 +/- 613 pg/min/ml。这些变量的组间差异无统计学意义。因此，精氨酸诱导的高胰高血糖素血症不能被确定为皮马印第安人糖尿病前期状态的特征。
To determine whether abnormalities in glucagon secretion might precede the onset of hyperglycemia in diabetes mellitus, 32 prediabetic Pima (American) Indians, 27 normal Pima Indians and 34 normal Caucasians received an infusion of arginine monochloride (5 mg/kg/min for 40 minutes) with measurement of glucose, insulin, and glucagon. [Prediabetes is the period between conception and the development of diabetes. In most studies the term is used to characterize patients who on genetic grounds are believed to be at high risk of developing the disease, including the normoglycemic monozygotic co-twin of a diabetic or the normoglycemic offspring of two diabetic parents. The latter definition is used in the present study recognizing that in the final analysis the true prediabetic can be identified only in retrospect after the development of diabetes.] The three groups had similar mean fasting glucagon levels. During arginine infusion, the prediabetic Indians reached a mean maximum glucagon level of 315 +/- 14 pg/ml (mean +/- 1 SEM) compared with 294 +/- 20 pg/ml in the normal Indians and 292 +/- 25 pg/ml in the normal Caucasians. The calculated mean areas above baseline under the glucagon curves were 5704 +/- 324 pg-min/ml in the prediabetics, 5189 +/- 446 pg-min/ml in the normal Indians, and 4239 +/- 613 pg/min/ml in the normal Caucasians. The differences among the groups in these variables were not statistically significant. Thus, arginine induced hyperglucagonemia could not be identified as a characteristic of the prediabetic state in Pima Indians.