Dysfunctional Activation of the Cerebellum in Schizophrenia: A Functional Neuroimaging Meta-Analysis.
Dysfunctional Activation of the Cerebellum in Schizophrenia: A Functional Neuroimaging Meta-Analysis.
复制标题
DOI：
10.1177/2167702614542463
复制
发表时间：
2015-07-01
期刊：
影响因子：
--
通讯作者：
Mittal VA
中科院分区：
文献类型：
--
作者：
Bernard JA;Mittal VA
认知辨距障碍框架假定精神分裂症中所见的缺陷是由于潜在的小脑-丘脑-皮质功能障碍。小脑被认为在运动和认知行为的内部模型的形成中至关重要。在健康个体中，小脑内存在功能性地形图。精神分裂症患者小脑功能地形图和激活的改变可能表明内部模型的改变，为这一框架提供支持。使用最先进的神经影像学荟萃分析，我们研究了精神分裂症患者与健康对照组相比，小脑激活在各种任务领域的影响。我们的研究结果表明，患者的功能地形改变。这在情绪和工作记忆任务中尤其明显，可能与这些领域的缺陷有关。结果表明，改变小脑功能地形在精神分裂症可能有助于许多赤字与疾病，可能是由于功能失调的内部模型。
The cognitive dysmetria framework postulates that the deficits seen in schizophrenia are due to underlying cerebello-thalamo-cortical dysfunction. The cerebellum is thought to be crucial in the formation of internal models for both motor and cognitive behaviors. In healthy individuals there is a functional topography within the cerebellum. Alterations in the functional topography and activation of the cerebellum in schizophrenia patients may be indicative of altered internal models, providing support for this framework. Using state-of-the-art neuroimaging meta-analysis, we investigated cerebellar activation across a variety of task domains affected in schizophrenia and in comparison to healthy controls. Our results indicate an altered functional topography in patients. This was especially apparent for emotion and working memory tasks, and may be related to deficits in these domains. Results suggest that an altered cerebellar functional topography in schizophrenia may be contributing to the many deficits associated with the disease, perhaps due to dysfunctional internal models.