Asthma The Interplay Between Viral Infections and Allergic Diseases
Asthma The Interplay Between Viral Infections and Allergic Diseases
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DOI：
10.1016/j.iac.2014.09.012
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发表时间：
2015-02-01
影响因子：
2.6
通讯作者：
Gill, Michelle A.
中科院分区：
文献类型：
--
作者：
Rowe, Regina K.;Gill, Michelle A.
呼吸道病毒和过敏原协同促进哮喘的发病机制。这种临床相关关联的潜在机制是深入研究的主题。本综述总结了该领域的当前知识和最新进展，重点关注涉及免疫球蛋白 E、I 型干扰素抗病毒反应、上皮因子的潜在机制，以及树突状细胞和其他抗原呈递细胞在与哮喘病相关的病毒和过敏性炎症反应之间的作用。
Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechanisms involving immunoglobulin E, type I interferon antiviral responses, epithelial factors, and the role of dendritic cells and other antigen-presenting cells in linking viral and allergic inflammatory responses relevant to asthmatic disease.