LIGUSTRAZINE IS A VASODILATOR OF HUMAN PULMONARY AND BRONCHIAL ARTERIES
LIGUSTRAZINE IS A VASODILATOR OF HUMAN PULMONARY AND BRONCHIAL ARTERIES
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DOI：
10.1016/0014-2999(90)94167-v
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发表时间：
1990-12-04
影响因子：
5
通讯作者：
BARNES, PJ
中科院分区：
文献类型：
--
作者：
LIU, SF;CAI, YN;BARNES, PJ
我们研究了川芎嗪（传统中草药的半合成原理）对人肺动脉和支气管动脉的体外扩张作用。 川芎嗪引起人肺小动脉的浓度依赖性松弛，这种松弛与内皮无关。 虽然川芎嗪在诱导肺动脉和支气管动脉扩张方面同样有效，但它在放松小肺动脉（内径 300-500 微米）方面的效力比肺叶动脉（内径 7-8 毫米）强约 10 倍。相比之下，小肺动脉和大叶肺动脉对硝普钠的松弛反应没有显着差异。川芎嗪在松弛前列腺素 F2-α 或 5-羟色胺预收缩的肺动脉方面同样有效，表明它不是前列腺素 F2-α 或 5-羟色胺拮抗剂。用普萘洛尔 (1-mu-M) 或吲哚美辛 (10-mu-M) 预孵育血管对川芎嗪诱导的血管舒张没有显着影响。 然而，当川芎嗪在无钙 K+ 去极化介质中应用于大鼠主动脉时，会引起浓度依赖性的钙诱发收缩抑制。 我们得出结论，川芎嗪是人肺动脉和支气管动脉的扩张剂，其与内皮无关，并且川芎嗪优先松弛肺阻力血管而不是大导管肺动脉。
We have investigated the dilator effect of ligustrazine, the semisynthetic principle of a traditional Chinese herbal remedy, on human pulmonary and bronchial arteries in vitro. Ligustrazine caused a concentration-dependent relaxation of human small pulmonary arteries, which was independent of endothelium. Although ligustrazine was equally potent in inducing dilatation of pulmonary and bronchial arteries, it was about 10 times more potent in relaxing small pulmonary arteries (300-500-mu-m i.d.) compared with lobar pulmonary arteries (7-8 mm i.d.). By contrast, the relaxant responses of small and lobar pulmonary arteries to sodium nitroprusside was not significantly different. Ligustrazine was equally potent in relaxing prostaglandin F2-alpha- or 5-hydroxytryptamine-precontracted pulmonary arteries, suggesting that it is not a prostaglandin F2-alpha or 5-hydroxytryptamine antagonist. Preincubating the vessels with propranolol (1-mu-M) or indomethacin (10- mu-M) had no significant effect on the ligustrazine-induced vasodilatation. However, ligustrazine caused concentration-dependent inhibition of calcium-evoked contraction when applied to rat aorta in calcium-free K+ -depolarizing medium. We conclude that ligustrazine is a dilator of human pulmonary and bronchial arteries, which is endothelium-independent and that ligustrazine preferentially relaxes pulmonary resistance vessels rather than large conduit pulmonary arteries.