NORADRENERGIC FUNCTION IN GENERALIZED ANXIETY DISORDER - EFFECTS OF YOHIMBINE IN HEALTHY-SUBJECTS AND PATIENTS WITH GENERALIZED ANXIETY DISORDER
NORADRENERGIC FUNCTION IN GENERALIZED ANXIETY DISORDER - EFFECTS OF YOHIMBINE IN HEALTHY-SUBJECTS AND PATIENTS WITH GENERALIZED ANXIETY DISORDER
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DOI：
10.1016/0165-1781(89)90132-7
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发表时间：
1989-02-01
影响因子：
11.3
通讯作者：
HENINGER, GR
中科院分区：
文献类型：
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作者：
CHARNEY, DS;WOODS, SW;HENINGER, GR
去甲肾上腺素能神经元系统的过度活跃与某些形式的人类焦虑的病理生理学有关的假设得到了广泛的临床前和临床支持。在本研究中，在20名广泛性焦虑症(GAD)患者和20名健康受试者中测定了对α2-肾上腺素能受体拮抗剂育亨宾的行为、生化和心血管反应。两组对育亨宾的反应大体相似，只是在 GAD 患者中，育亨宾诱导的血浆 3-甲氧基-4-羟基苯基二醇的增加有较少的趋势。这些发现与之前关于育亨宾对惊恐障碍患者的影响的研究形成鲜明对比，从而支持这两种疾病之间的神经生物学区别。
There is extensive preclinical and clinical support for the hypothesis that hyperactivity of noradrenergic neuronal systems is related to the pathophysiology of some forms of human anxiety. In the present investigation, the behavioral, biochemical, and cardiovascular responses to the .alpha.2-adrenergic receptor antagonist, yohimbine, was determined in 20 patients with generalized anxiety disorder (GAD) and 20 healthy subjects. The responses to yohimbine were generally similar in the two groups except there was a trend for the yohimbine-induced increase in plasma 3-methoxy-4-hydroxyphenylglycol to be less in the GAD patients. These findings contrast with previous studies of the effects of yohimbine in panic disorder patients and, thereby, support a neurobiological distinction between these two disorders.