MACROPHAGE/PARTICLE INTERACTIONS - EFFECT OF SIZE, COMPOSITION AND SURFACE-AREA
MACROPHAGE/PARTICLE INTERACTIONS - EFFECT OF SIZE, COMPOSITION AND SURFACE-AREA
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DOI：
10.1002/jbm.820280111
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发表时间：
1994-01-01
期刊：
影响因子：
--
通讯作者：
GLANT, TT
中科院分区：
文献类型：
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作者：
SHANBHAG, AS;JACOBS, JJ;GLANT, TT
在邻近松动关节假体的肉芽肿组织的组织细胞/巨噬细胞中检测到颗粒状磨损碎屑。这种细胞-颗粒相互作用已经通过用根据颗粒的重量百分比、体积百分比和数量给药的颗粒挑战巨噬细胞来体外模拟。由于不同组成的挑战性颗粒的尺寸和密度不同，这些给药方法中的每一种都具有固有的缺点。在这项研究中，我们用二氧化钛和聚苯乙烯颗粒攻击P388 D（1）巨噬细胞（
Particulate wear-debris are detected in histiocytes/macrophages of granulomatous tissues adjacent to loose joint prostheses. Such cell-particle interactions have been simulated invitro by challenging macrophages with particles dosed according to weight percent, volume percent, and number of particles. Each of these dosage methods has inherent shortcomings due to varying size and density of challenging particles of different compositions. In this study we challenged P388D(1) macrophages with titania and polystyrene particles (