Transient synchronization of hippocampo-striato-thalamo-cortical networks during sleep spindle oscillations induces motor memory consolidation
Transient synchronization of hippocampo-striato-thalamo-cortical networks during sleep spindle oscillations induces motor memory consolidation
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DOI：
10.1016/j.neuroimage.2017.12.066
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发表时间：
2018-04-01
期刊：
影响因子：
5.7
通讯作者：
Doyon, Julien
中科院分区：
文献类型：
--
作者：
Boutin, Arnaud;Pinsard, Basile;Doyon, Julien
睡眠有利于运动记忆的巩固。这种记忆过程被认为是由NREM-阶段2睡眠事件期间的丘脑皮质纺锤体活动以及纹状体和海马活动的变化介导的。然而，支持这种睡眠依赖性生理机制对人类运动记忆巩固的贡献的直接实验证据缺乏。在本研究中，我们结合EEG和功能磁共振成像睡眠记录的运动序列学习（MSL）任务的做法，以确定是否梭振荡支持睡眠依赖的运动记忆巩固的瞬时同步和协调专门的皮层和皮层下网络。为此，我们在皮层和皮层下区域使用新的深源定位技术进行了脑电源重建的纺锤体时期。采用基于相干性的度量来估计特定频带上皮层和皮层下结构之间的功能连接。我们的研究结果不仅证实了NREM第2阶段睡眠纺锤波在运动技能巩固中的关键和功能作用，而且首次提供证据表明，纺锤波振荡[11-17 Hz]可能通过局部重新激活和功能结合特定任务相关的皮层和皮层下区域网络（包括海马体，壳核，丘脑和运动相关皮层区域）参与睡眠依赖性运动记忆巩固。
Sleep benefits motor memory consolidation. This mnemonic process is thought to be mediated by thalamocortical spindle activity during NREM-stage2 sleep episodes as well as changes in striatal and hippocampal activity. However, direct experimental evidence supporting the contribution of such sleep-dependent physiological mechanisms to motor memory consolidation in humans is lacking. In the present study, we combined EEG and fMRI sleep recordings following practice of a motor sequence learning (MSL) task to determine whether spindle oscillations support sleep-dependent motor memory consolidation by transiently synchronizing and coordinating specialized cortical and subcortical networks. To that end, we conducted EEG source reconstruction on spindle epochs in both cortical and subcortical regions using novel deep-source localization techniques. Coherence-based metrics were adopted to estimate functional connectivity between cortical and subcortical structures over specific frequency bands. Our findings not only confirm the critical and functional role of NREM-stage2 sleep spindles in motor skill consolidation, but provide first-time evidence that spindle oscillations [11-17 Hz] may be involved in sleep-dependent motor memory consolidation by locally reactivating and functionally binding specific taskrelevant cortical and subcortical regions within networks including the hippocampus, putamen, thalamus and motor-related cortical regions.