Validation of the PedsQL Epilepsy Module: A pediatric epilepsy-specific health-related quality of life measure
Validation of the PedsQL Epilepsy Module: A pediatric epilepsy-specific health-related quality of life measure
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DOI：
10.1111/epi.13875
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发表时间：
2017-11-01
期刊：
影响因子：
5.6
通讯作者：
Varni, James W.
中科院分区：
文献类型：
--
作者：
Modi, Avani C.;Junger, Katherine F.;Varni, James W.
目的：为了验证一个简短而可靠的癫痫特异性，健康相关的生活质量（HRQOL）的措施，在儿童与各种癫痫发作类型，治疗，和人口统计学特征。方法：这项国家验证研究在美国的五个癫痫中心进行。5-18岁的青少年和2-18岁诊断为癫痫的青少年的照顾者完成了PedsQL癫痫模块和其他问卷，以建立癫痫特异性HRQOL工具的可靠性和有效性。通过病历审查收集人口统计学和医学数据。进行因素分析，和内部一致性（克朗巴赫的阿尔法），重测信度，结构效度进行了assessed.Results：从430名儿童癫痫（M-年龄= 9.9岁，范围2-18岁，46%的女性，62%的白色：非西班牙裔，76%的单药治疗，54%的活动性癫痫发作）和他们的照顾者进行了分析。最终的PedsQL癫痫模块是一个29项测量，包括5个分量表（即，影响，认知，睡眠，执行功能和情绪/行为）与平行的儿童和照顾者的报告。内部一致性系数范围为0.70-0.94。结构的有效性和收敛表现在几个方面，包括与癫痫发作的结果，抗癫痫药物（AED）的副作用，以及执行，认知和情绪/行为functioning.Significance建立措施的强大关系：PedsQL癫痫模块是一个可靠的衡量HRQOL与其有效性的强有力的证据，在临床和研究设置的癫痫频谱。
Objective: To validate a brief and reliable epilepsy-specific, health-related quality of life (HRQOL) measure in children with various seizure types, treatments, and demographic characteristics.Methods: This national validation study was conducted across five epilepsy centers in the United States. Youth 5-18 years and caregivers of youth 2-18 years diagnosed with epilepsy completed the PedsQL Epilepsy Module and additional questionnaires to establish reliability and validity of the epilepsy-specific HRQOL instrument. Demographic and medical data were collected through chart reviews. Factor analysis was conducted, and internal consistency (Cronbach's alphas), test-retest reliability, and construct validity were assessed.Results: Questionnaires were analyzed from 430 children with epilepsy (M-age = 9.9 years; range 2-18 years; 46% female; 62% white: non-Hispanic; 76% monotherapy, 54% active seizures) and their caregivers. The final PedsQL Epilepsy Module is a 29-item measure with five subscales (i.e., Impact, Cognitive, Sleep, Executive Functioning, and Mood/Behavior) with parallel child and caregiver reports. Internal consistency coefficients ranged from 0.70-0.94. Construct validity and convergence was demonstrated in several ways, including strong relationships with seizure outcomes, antiepileptic drug (AED) side effects, and well-established measures of executive, cognitive, and emotional/behavioral functioning.Significance: The PedsQL Epilepsy Module is a reliable measure of HRQOL with strong evidence of its validity across the epilepsy spectrum in both clinical and research settings.