Nuclear Medicine Imaging For Prediction or Early Assessment of Response to Chemotherapy in Patients Suffering From Breast Carcinoma
Nuclear Medicine Imaging For Prediction or Early Assessment of Response to Chemotherapy in Patients Suffering From Breast Carcinoma
复制标题
核医学成像用于预测或早期评估乳腺癌患者化疗的反应
DOI：
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发表时间：
2002
影响因子：
3.8
通讯作者：
A. Signore
中科院分区：
文献类型：
--
作者：
C. Van de Wiele;R. Dierckx;F. Scopinaro;R. Waterhouse;A. Annovazzi;A. Kolindou;A. Signore
可以更快地评估治疗反应或甚至预测乳腺肿瘤对化疗的反应性的可靠测定将是非常有价值的，因为它们将允许在早期阶段调整无效治疗和停止无效治疗。与有效的癌症治疗一样，肿瘤生理学、代谢和增殖的变化通常先于通过形态学成像方式（例如放射照相术和计算机断层扫描）常规测量的体积变化，通过单光子发射计算机断层扫描（SPECT）或正电子发射断层扫描评估这些参数可以提供肿瘤细胞死亡或生长抑制的更灵敏和更早的标志物。本文回顾了现有的文献SPECT和PET在乳腺肿瘤代谢（葡萄糖利用率和蛋白质合成率）的测量和可视化的作用，细胞凋亡诱导和化疗耐药机制的预测或肿瘤反应或化疗方案无反应的早期标志物患有乳腺癌的患者。
Reliable assays that could assess treatment response more rapidly or even predict responsiveness of breast tumours to chemotherapy would be very valuable as they would allow for adjustment of ineffective treatment and discontinuation of ineffective treatment in an early phase. As with effective cancer therapy, changes in tumour physiology, metabolism and proliferation do often precede volumetric changes routinely measured by morphological imaging modalities, for example, radiography and computerized tomography, assessment of these parameters by means of single photon emission computerized tomography (SPECT) or positron emission tomography may provide more sensitive and earlier markers of tumour cell death or growth inhibition. This paper reviews the available literature on the role of SPECT and PET in the measurement and visualisation of breast tumour metabolism (glucose utilization and protein synthesis rate), apoptosis induction and chemotherapy resistance mechanisms as predictors or early markers of tumour response or non-response to chemotherapeutic options in patients suffering from breast carcinoma.
影响因子：
45.3
作者：
WAHL, RL;ZASADNY, K;CODY, R
通讯作者：
CODY, R