Relative role of insulin resistance and β-cell dysfunction in the progression to type 2 diabetes -: The Kinmen Study
Relative role of insulin resistance and β-cell dysfunction in the progression to type 2 diabetes -: The Kinmen Study
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DOI：
10.1016/s0168-8227(02)00249-8
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发表时间：
2003-03-01
影响因子：
5.1
通讯作者：
Chou, P
中科院分区：
文献类型：
--
作者：
Li, CL;Tsai, ST;Chou, P
本研究比较了胰岛素抵抗和P细胞功能障碍（均使用HOMA方法评估）与葡萄糖耐受不良状况在台湾金门空腹血糖（FPG）5.6-7.0 mmol/l的高危受试者中进展为2型糖尿病的相对作用。数据收集于一项持续的前瞻性研究（1998-99）中，研究对象为一组具有空腹高血糖的2型糖尿病高危台湾受试者。（5.6-7.0 mmol/l），从1992-94年至1995-96年，2小时负荷后血糖浓度< 11.1 mmol/l。在基线时的644例非糖尿病受试者中，79.8%（514/644）至少接受了一次随访检查。在2918.7人年的随访中，有107例新发糖尿病病例按1999年WHO标准诊断。发病率为3.67%/年（107/2918.7）。在调整了其他可能的相关变量后，包括性别、年龄、BMI、腰围、胰岛素抵抗和P细胞功能障碍，考克斯的风险模型显示，那些患有孤立性IFG（空腹血糖受损）的个体和那些患有孤立性IGT（2小时血糖受损）的个体显示出相似的发展为糖尿病的风险。那些患有单纯IFG和单纯IGT的个体显示出相当的基础或肝脏胰岛素敏感性损害，但那些患有单纯IFG的个体具有更大的β细胞功能障碍。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
This study compared the relative role of insulin resistance and P-cell dysfunction (both assessed using the HOMA method) with glucose intolerance conditions in the progression to type 2 diabetes among a high risk group of subjects with fasting plasma glucose (FPG) 5.6-7.0 mmol/l in Kinmen, Taiwan. Data were collected during a continuing prospective study (1998-99) of a group of Taiwanese subjects at high-risk of developing type 2 diabetes who had fasting hyperglycemia. (5.6-7.0 mmol/l) and exhibited 2-h postload glucose concentrations < 11.1 mmol/l from 1992-94 to 1995-96. Among 644 non-diabetic subjects at baseline, 79.8% (514/644) had at least one follow-up examination. There were 107 new cases of diabetes diagnosed by 1999 WHO criteria in 2918.7 person-years of follow-up. The incidence rate was 3.67%/year (107/2918.7). After adjustment for other possible associative variables, including gender, age, BMI, waist circumference, insulin resistance, and P-cell dysfunction, Cox's hazard model showed that those individuals with isolated IFG (impaired fasting glucose) and those individuals with isolated IGT (2-h glucose impairment) exhibited similar risk of developing diabetes. Those individuals with isolated IFG and isolated IGT showed a comparable impairment of basal or hepatic insulin sensitivity, but those individuals with isolated IFG had a greater β-cell dysfunction by the HOMA method. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.