Neurocognitive functioning and genetic variation in patients with primary brain tumours.
Neurocognitive functioning and genetic variation in patients with primary brain tumours.
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DOI：
10.1016/s1470-2045(15)00380-0
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发表时间：
2016-03
期刊：
影响因子：
51.1
通讯作者：
Scheurer, Michael E.
中科院分区：
文献类型：
--
作者：
Wefel, Jeffrey S.;Noll, Kyle R.;Scheurer, Michael E.
Impairment of neurocognitive functioning is a common consequence of cerebral neoplasms and treatment, though considerable heterogeneity exists in the pattern and severity of problems across individuals and tumor types. While the influence of numerous clinical and patient characteristics have been documented, relatively little research has been devoted to understanding the influence of genetic variation upon neurocognitive outcomes in patients with brain tumors. This review highlights preliminary evidence associating genes from diverse pathways with risk of adverse neurocognitive outcomes in brain tumor patients, including genes specific to neuronal function and those involved in more systemic cellular regulation. Related literature involving other disease populations is also briefly surveyed, pointing to additional candidate genes. Methodological considerations are also discussed and the need for future research integrating novel investigative techniques is emphasized.
