Changes in the functional MR signal in motor and non-motor areas during intermittent fatiguing hand exercise
Changes in the functional MR signal in motor and non-motor areas during intermittent fatiguing hand exercise
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DOI：
10.1007/s00221-007-0973-5
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发表时间：
2007-09-01
影响因子：
2
通讯作者：
Thickbroom, Gary W.
中科院分区：
文献类型：
--
作者：
Benwell, Nicola M.;Mastaglia, Frank L.;Thickbroom, Gary W.
本研究的目的是确定在单侧手部疲劳运动期间，大脑半球运动和非运动区域的功能磁共振成像（fMRI）信号的时间过程是否有显著变化。在fMRI扫描期间，12名受试者进行了次最大（30%）间歇性疲劳握拳运动（握拳3秒，左手松开2秒），时间约为9分钟。采用回归分析测量两脑半球初级感觉运动皮层（SM1）、运动前皮层和视觉皮层（V1）的fMRI信号变化。力下降到疲劳前最大力的77 +/- 3.6% （P < 0.05）。疲劳手SM1对侧fMRI信号较基线增加1.2±0.5% （P < 0.05）。同侧SM1的fMRI信号无明显变化。运动前皮层也表现出类似的模式，但没有达到显著性。两半球V1信号显著增加（对侧1.3 +/- 0.9%，同侧1.5 +/- 0.9%,P < 0.05）。在进行单一的、次最大的疲劳运动时，运动和非运动区域的激活增加。这一结果与在疲劳运动中增加感觉处理和皮质运动驱动的概念相一致，以保持疲劳发展时的任务表现。
The aim of this study was to determine whether there were significant changes in the time course of the functional magnetic resonance imaging (fMRI) signal in motor and non-motor regions of both cerebral hemispheres during a unilateral fatiguing exercise of the hand. Twelve subjects performed a submaximal (30%) intermittent fatiguing handgrip exercise (3 s grip, 2 s release, left hand) for similar to 9 min during fMRI scanning. Regression analysis was used to measure changes in fMRI signal from primary sensorimotor cortex (SM1), premotor cortex and visual cortex (V1) in both hemispheres. Force declined to 77 +/- 3.6% of prefatigue maximal force (P < 0.05). The fMRI signal from SM1 contralateral to the fatiguing hand increased by 1.2 +/- 0.5% of baseline (P < 0.05). The fMRI signal from the ipsilateral SM1 did not change significantly. Premotor cortex showed a similar pattern but did not reach significance. The signal from V1 increased significantly for both hemispheres (contralateral 1.3 +/- 0.9%, ipsilateral 1.5 +/- 0.9% of baseline and P < 0.05). During the performance of a unimanual, submaximal fatiguing exercise there is an increase in activation of motor and non-motor regions. The results are in keeping with the notion of an increase in sensory processing and corticomotor drive during fatiguing exercise to maintain task performance as fatigue develops.