Induction of lymphopenia and inhibition of T cell function during acute infection of swine with foot and mouth disease virus (FMDV)
Induction of lymphopenia and inhibition of T cell function during acute infection of swine with foot and mouth disease virus (FMDV)
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DOI：
10.1016/s0165-2427(03)00004-7
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发表时间：
2003-03-20
影响因子：
1.8
通讯作者：
Golde, WT
中科院分区：
文献类型：
--
作者：
Bautista, EM;Ferman, GS;Golde, WT
口蹄疫病毒(FMDV)是一种小核糖核酸病毒，可引起偶蹄动物的一种急性水泡病。这种病毒继续对全世界的牲畜构成威胁，暴发造成严重的经济损失。本研究分析了猪口蹄疫病毒感染急性期免疫系统的表型和功能。在感染的最初几天，观察到明显的淋巴细胞减少，涉及所有T细胞亚群，即CD4(+)、CD8(+)和CD4(+)/CD8(+)。这种明显的淋巴细胞减少并不是PBMC主动感染病毒的结果。此外，残留外周血T细胞对有丝分裂原刀豆蛋白A(ConA)的反应显著降低，有时甚至被消除。动物通常会解决疾病的临床症状，产生对病毒的抗原特异性T细胞反应，并恢复ConA的反应性。急性期感染的这些特征可能在病毒的致病机制、病毒颗粒的传播和脱落中发挥重要作用，并可能被作为改进疫苗配方的一种方式。(C)2003 Elsevier Science B.V.保留所有权利。
Foot and mouth disease virus (FMDV) is a picornavirus that causes an acute vesicular disease of cloven-hoofed animals. This virus continues to be a threat to livestock worldwide with outbreaks causing severe economic losses. The present study shows an analysis of immune system phenotype and function during the acute phase of FMDV infection in swine. In the first days of infection, a significant lymphopenia is observed that involves all T cell subsets, CD4(+), CD8(+), and CD4(+)/CD8(+). This marked lymphopenia is not a result of active infection of PBMC with the virus. Further, the response of residual peripheral blood T cells to the mitogen, Concanavalin A (ConA) is significantly reduced and occasionally eliminated. Animals usually resolve clinical signs of disease and develop antigen specific T cell responses to the virus and recover ConA reactivity. These characteristics of acute phase infection likely play an important role in viral pathogenesis, propagation and shedding of viral particles and may be targeted as a way of improving vaccine formulations. (C) 2003 Elsevier Science B.V. All rights reserved.