Frequency and predictors of obstructive sleep apnea among individuals with major depressive disorder and insomnia
Frequency and predictors of obstructive sleep apnea among individuals with major depressive disorder and insomnia
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DOI：
10.1016/j.jpsychores.2009.03.011
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发表时间：
2009-08-01
影响因子：
4.7
通讯作者：
Manber, Rachel
中科院分区：
文献类型：
--
作者：
Ong, Jason C.;Gress, Jenna L.;Manber, Rachel
目的：睡眠连续性障碍在重度抑郁症（MDD）患者中很常见，可能会影响抑郁症的病程和对治疗的反应。几项研究调查了阻塞性睡眠呼吸暂停（OSA）睡眠障碍患者的抑郁症状严重程度。相比之下，对MDD患者的OSA知之甚少。本研究的目的是在抑郁症和失眠症共病的个体样本中检查OSA的频率和预测因素。研究方法：参与者是51名参与失眠和抑郁症治疗研究的个体，符合MDD和共病失眠的标准，并接受了夜间多导睡眠图评估。呼吸暂停低通气指数>= 15次/小时被用作OSA的截止评分。通过回归分析来研究临床和人口统计学上的预测因素，这些预测因素是通过呼吸暂停低通气指数来测量的。结果：结果显示，39%的样本符合OSA标准。OSA组的身体质量指数（BMI）评分显著较高，男性比例显著较高。回归分析显示，男性，年龄较大，体重指数较高的OSA严重程度的显着预测。抑郁严重程度和失眠严重程度都不是显著的预测因子。结论：这些研究结果表明，合并MDD和失眠的个体中OSA的发生率高于先前在MDD或失眠单独人群中发现的。此外，以前确定的OSA预测因素（男性、年龄较大和BMI较高）也适用于这一人群。(C)2009 Elsevier Inc. All rights reserved.
Objective: Disturbances in sleep continuity are common among individuals with major depressive disorder (MDD) and can impact the course of depression and response to treatment. Several studies have examined depressive symptom severity among sleep-disordered patients with obstructive sleep apnea (OSA). In contrast, little is known about OSA in patients with MDD. The goal of this study was to examine the frequency and predictors of OSA in a sample of individuals with comorbid MDD and insomnia. Methods: Participants were 51 individuals who enrolled in a treatment study on insomnia and depression, met criteria for MDD and comorbid insomnia, and underwent an overnight polysomnography evaluation. An apnea-hypopnea index >= 15 events per hour was used as a cutoff score for OSA. Regression analyses were conducted to examine clinical and demographic predictors of OSA severity as measured by the apnea-hypopnea index. Results: The results revealed that 39% of the sample met criteria for OSA. The OSA group had significantly higher body mass index (BMI) scores and a significantly greater proportion of men. Regression analysis revealed that male sex, older age, and higher BMI were significant predictors of OSA severity. Neither depression severity nor insomnia severity was a significant predictor. Conclusions: These findings indicate that the frequency of OSA is higher among individuals with comorbid MDD and insomnia than was previously found among people with either MDD or insomnia alone. In addition, previously identified predictors of OSA (male sex, older age, and high BMI) also apply to this population. (C) 2009 Elsevier Inc. All rights reserved.