Reduced hippocampal subfield volumes and memory function in school-aged children born preterm with very low birthweight (VLBW)
Reduced hippocampal subfield volumes and memory function in school-aged children born preterm with very low birthweight (VLBW)
复制标题
DOI：
10.1016/j.nicl.2019.101857
复制
发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Skranes, Jon
中科院分区：
文献类型：
--
作者：
Aanes, Synne;Bjuland, Knut Jorgen;Skranes, Jon
背景资料：海马是学习和记忆的重要结构，在早产（胎龄< 37周）的极低出生体重（VLBW：出生体重<1500 g）个体中具有减小的体积，这可能影响记忆功能。然而，海马体是一个复杂的结构，具有与特定记忆功能相关的不同子域。这些子场受到各种神经病理学条件的不同影响，但目前尚不清楚这些子场如何受到早产后可能导致异常大脑发育的医学并发症的影响，以及其对VLBW儿童学习和记忆功能的影响。方法：早产VLBW儿童（n = 34）和来自挪威母婴队列研究（MoBa）的足月对照儿童（n = 104）在小学年龄接受了结构MRI和记忆功能的神经心理学评估。使用FreeSurfer 6.0分析各组之间比较的海马子区体积，以及记忆表现。VLBW group.Results：所有绝对海马子区体积VLBW的儿童相比，MoBa term-born对照组，和左，右齿状回和右下托的体积仍然显着降低校正后的颅内总体积异常海马子区和记忆performance之间的相关性进行了探讨。VLBW组有较差的工作记忆性能和分数上的子测试空间跨度向后正相关的右齿状回的体积。结论：海马子域卷似乎受到不同的影响，早期脑发育有关早产。齿状回似乎特别容易受到早产的不利影响。极低出生体重儿童工作记忆功能下降与右侧齿状回体积较小有关。这一发现表明海马结构功能关系的改变与早产相关的早期脑发育有关。
Background: The hippocampus, an essential structure for learning and memory, has a reduced volume in preterm born (gestational age < 37 weeks) individuals with very low birth weight (VLBW: birth weight < 1500g), which may affect memory function. However, the hippocampus is a complex structure with distinct subfields related to specific memory functions. These subfields are differentially affected by a variety of neuropathological conditions, but it remains unclear how these subfields may be affected by medical complications following preterm birth which may cause aberrant brain development, and the consequences of this on learning and memory function in children with VLBW.Methods: Children born preterm with VLBW (n = 34) and term-born controls from the Norwegian Mother and Child Cohort Study (MoBa) (n = 104) underwent structural MRI and a neuropsychological assessment of memory function at primary school age. FreeSurfer 6.0 was used to analyze the volumes of hippocampal subfields which were compared between groups, as was memory performance. Correlations between abnormal hippocampal subfields and memory performance were explored in the VLBW group.Results: All absolute hippocampal subfield volumes were lower in the children with VLBW compared to MoBa term-born controls, and the volumes of the left and right dentate gyrus and the right subiculum remained significantly lower after correcting for total intracranial volume. The VLBW group had inferior working memory performance and the score on the subtest Spatial Span backwards was positively correlated to the volume of the right dentate gyrus.Conclusions: Hippocampal subfield volumes seem to be differently affected by early brain development related to preterm birth. The dentate gyrus appears particularly susceptible to adverse effects of preterm birth. Reduced working memory function among children with VLBW was associated with smaller volume of right dentate gyrus. This finding demonstrates alterations in hippocampal structure-function relationships associated with early brain development related to preterm birth.