Anomalous diffusion due to binding: A Monte Carlo study
Anomalous diffusion due to binding: A Monte Carlo study
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DOI：
10.1016/s0006-3495(96)79682-0
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发表时间：
1996-03-01
影响因子：
3.4
通讯作者：
Saxton, MJ
中科院分区：
文献类型：
--
作者：
Saxton, MJ
在经典扩散中，均方位移随时间线性增加。但在障碍物或结合位点的存在下，可能会发生异常扩散，其中均方位移在某些或所有时间与时间的非整数幂成比例。异常扩散讨论了各种模型的结合，包括一个障碍/结合模型，其中不动的膜蛋白表示的障碍，结合扩散粒子在最近的邻居网站。结合模型的分类被认为是，包括谷和山模型之间的区别和奇异和非奇异的结合能分布之间的区别。反常扩散对测量的初始条件很敏感。在谷模型中，如果扩散粒子在随机位置开始，扩散是反常的，但如果粒子在热平衡位置开始，扩散是正常的。热平衡导致正常扩散，或者在障碍物允许的情况下导致正常扩散。
In classical diffusion, the mean-square displacement increases linearly with time. But in the presence of obstacles or binding sites, anomalous diffusion may occur, in which the mean-square displacement is proportional to a nonintegral power of time for some or all times. Anomalous diffusion is discussed for various models of binding, including an obstruction/binding model in which immobile membrane proteins are represented by obstacles that bind diffusing particles in nearest-neighbor sites. The classification of binding models is considered, including the distinction between valley and mountain models and the distinction between singular and nonsingular distributions of binding energies. Anomalous diffusion is sensitive to the initial conditions of the measurement. in valley models, diffusion is anomalous if the diffusing particles start at random positions but normal if the particles start at thermal equilibrium positions. Thermal equilibration leads to normal diffusion, or to diffusion as normal as the obstacles allow.