Rich-Club Analysis in Adults With ADHD Connectomes Reveals an Abnormal Structural Core Network
Rich-Club Analysis in Adults With ADHD Connectomes Reveals an Abnormal Structural Core Network
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患有 ADHD 连接体的成年人的丰富俱乐部分析揭示了异常的结构核心网络
DOI：
10.1177/1087054719883031
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发表时间：
2019-10-23
影响因子：
3
通讯作者：
Zhao, Shuo
中科院分区：
文献类型：
--
作者：
Wang, Bing;Wang, Gongshu;Zhao, Shuo
目的：注意力缺陷多动障碍（ADHD）是否存在大脑富俱乐部结构的异常连接体尚不清楚。方法：目前的研究使用弥散张量成像（DTI）和静息态功能磁共振成像（fMRI）来比较42名ADHD成年人和59名典型发育（TD）成年人的表现。结果如下：在ADHD的成年人中，发现结构枢纽节点之间的丰富俱乐部密度降低，包括双侧楔前叶，尾状核，左壳核和右距状核。此外，ADHD患者的整体效率低于TD患者，这可能是由于ADHD患者的富人俱乐部连接密度降低所致。结论：考虑到ADHD成年人的结构和功能连接之间的耦合强度大于TD成年人，连接体异常与丰富的俱乐部连接密度降低可能伴随着ADHD患者的功能性脑动力学改变。
Objective: Whether the abnormal connectome of brain's rich-club structure in adults with attention-deficit hyperactivity disorder (ADHD) remains unclear. Method: The current study used diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) to compare the performance of 42 adults with ADHD and 59 typical development (TD) adults. Results: A reduced density of rich-clubs among structural hub nodes, including the bilateral precuneus, the insula, the caudate nucleus, the left putamen, and the right calcarine, was found in adults with ADHD. Moreover, lower global efficiency was found in adults with ADHD than in TD, which might be caused by a reduced density of rich-club connections in ADHD patients. Conclusion: Given that adults with ADHD have greater coupling strength between structural and functional connectivity than TD adults, connectome abnormalities with a reduced rich-club connectivity density might be accompanied by altered functional brain dynamics in ADHD patients.