Two new unsaturated fatty acids from the mangrove rhizosphere soil-derived fungus Penicillium javanicum HK1-22
Two new unsaturated fatty acids from the mangrove rhizosphere soil-derived fungus Penicillium javanicum HK1-22
复制标题
红树林根际土源真菌爪哇青霉 HK1-22 中的两种新不饱和脂肪酸
DOI：
10.1016/j.bioorg.2019.103331
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发表时间：
2019-12-01
影响因子：
5.1
通讯作者：
Wang, Chang-Yun
中科院分区：
文献类型：
--
作者：
Liang, Zhao-Yang;Shen, Nan-Xing;Wang, Chang-Yun
从红树林根际土源真菌青霉HK1-22中分离出两个新的不饱和脂肪酸6R， 8r -二羟基-9Z， 12z -十八烯二烯酸(1)和甲基6R， 8r -二羟基-9Z， 12z -十八烯二烯酸(2)，以及两个已知的9Z， 12z -十八烯二烯酸类似物（3,4）和一个已知的倍半萜类(5)。还制备了1的丙酮衍生物（1a）。通过分析1a的一维和二维NOE光谱，确定了1的相对构型。根据生物遗传学的考虑，确定了1的绝对构型。测定了高产化合物5对4种作物病原菌的抑菌活性，结果表明，化合物5对4种作物病原菌均有显著的抑菌活性。
Two new unsaturated fatty acids, 6R,8R-dihydroxy-9Z,12Z-octadecadienoic acid (1) and methyl-6R,8R-dihydroxy-9Z,12Z-octadecadienoate (2), and two known 9Z,12Z-octadecadienoic acid analogues (3, 4) together with a known sesquiterpenoid (5) were isolated from the mangrove rhizosphere soil-derived fungus Penicillium javanicum HK1-22. An acetonide derivative (1a) from 1 was also prepared. The relative configuration of 1 was determined by analysis of the 1D and 2D NOE spectra of 1a. The absolute configuration of 1 was assigned on the basis of biogenetic considerations. The antifungal activity of the high yield compound 5 was evaluated against four strains of crop pathogens and it showed significant antifungal activities against all the tested strains.