Epstein-Barr virus-positive follicular lymphoma
Epstein-Barr virus-positive follicular lymphoma
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DOI：
10.1038/modpathol.2016.214
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发表时间：
2017-04-01
期刊：
影响因子：
7.5
通讯作者：
Chapman, Jennifer
中科院分区：
文献类型：
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作者：
Mackrides, Nicholas;Campuzano-Zuluaga, German;Chapman, Jennifer
爱泼斯坦-巴尔病毒(EBV)相关滤泡性淋巴瘤的报道很少。在这里，我们报告了最大的一系列分析EBV相关滤泡性淋巴瘤的发病率和临床病理特征的未选定病例。在382例分析病例中，发现10例EBV阳性滤泡性淋巴瘤(患病率=2.6%，95%可信区间1.3-4.0%)。所有EBV阳性滤泡性淋巴瘤均表现为滤泡性分布的EBV编码的小RNA阳性淋巴瘤细胞。其中8例也有可用于检测潜伏膜蛋白1(LMP1)表达的组织，其中6例(75%)呈阳性。与3A~3B级滤泡性淋巴瘤显著相关(P
Epstein-Barr virus (EBV) -associated follicular lymphoma is only rarely reported. Herein, we report the largest series analyzing prevalence and clinicopathologic characteristics of EBV-associated follicular lymphoma occurring in unselected cases. Out of 382 analyzed cases, 10 EBV-positive follicular lymphomas were identified (prevalence = 2.6%, 95% confidence interval 1.3-4.0%). All EBV-positive follicular lymphomas showed EBV-encoded small RNA-positive lymphoma cells present in a follicular distribution. Of these, eight also had tissue available for testing of expression of latent membrane protein 1 (LMP1), out of which six (75%) were positive. There was a significant association with grades 3A-3B follicular lymphoma (P