Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation:: an international case-control study
Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation:: an international case-control study
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DOI：
10.1182/blood-2004-09-3411
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发表时间：
2005-05-15
期刊：
影响因子：
20.3
通讯作者：
Deeg, HJ
中科院分区：
文献类型：
--
作者：
Curtis, RE;Metayer, C;Deeg, HJ
以前对造血干细胞移植受者的研究表明，移植物抗宿主病(GVHD)及其治疗可能会增加实体癌的风险，特别是口腔和皮肤的鳞状细胞癌(SCCs)。然而，这些联系的重要性和规模并没有得到很好的描述。我们对全球215个中心24011名接受造血干细胞移植(HSCT)的患者中的183名移植后实体癌患者(58名SCC，125名非SCC)和501名匹配的对照组患者进行了病例对照研究。我们的结果表明，慢性移植物抗宿主病及其治疗与鳞状细胞癌的风险密切相关，而非鳞状细胞癌的风险没有增加。慢性移植物抗宿主病治疗时间长是鳞状细胞癌发生的主要危险因素(P
Previous studies of recipients of hematopoietic stem-cell transplants suggest that graft-versus-host disease (GVHD) and its therapy may increase the risk for solid cancers, particularly squamous-cell carcinomas (SCCs) of the buccal cavity and skin. However, the importance and magnitude of these associations are not well characterized. We conducted a case-control study of 183 patients with post-transplantation solid cancers (58 SCCs, 125 non-SCCs) and 501 matched control patients within a cohort of 24 011 patients who underwent hematopoietic stem-cell transplantation (HSCT) at 215 centers worldwide. Our results showed that chronic GVHD and its therapy were strongly related to the risk for SCC, whereas no increase in risk was found for non-SCCs. Major risk factors for the development of SCC were long duration of chronic GVHD therapy (P