Zika virus infection confers protection against West Nile virus challenge in mice.
Zika virus infection confers protection against West Nile virus challenge in mice.
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DOI：
10.1038/emi.2017.68
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发表时间：
2017-09-20
影响因子：
13.2
通讯作者：
Jiménez de Oya N
中科院分区：
文献类型：
--
作者：
Vázquez-Calvo Á;Blázquez AB;Escribano-Romero E;Merino-Ramos T;Saiz JC;Martín-Acebes MA;Jiménez de Oya N
黄病毒是RNA病毒，对全球人类和动物健康构成令人担忧的威胁。寨卡病毒（ZIKV）最初被报道会导致一种轻微的疾病，最近在美洲传播，感染了数百万人。在最近的疫情期间，寨卡病毒感染与严重神经系统疾病和出生缺陷有关，特别是Guillain-Barrè综合征和小头畸形。由于关于寨卡病毒免疫的信息仍然稀缺，我们评估了免疫功能正常的小鼠对来自不同地理来源（非洲、亚洲和美洲）的三种病毒株感染的体液反应。没有受感染的动物表现出任何疾病迹象或在感染后死亡。然而，特异性中和抗体在所有感染小鼠中被激发。考虑到寨卡病毒在美洲大陆的快速传播及其与西尼罗河病毒（WNV）等其他医学相关黄病毒的共传播，分析了寨卡病毒与西尼罗河病毒之间的保护性免疫诱导。值得注意的是，在先前感染寨卡病毒的小鼠中观察到西尼罗河病毒攻击后的保护作用，存活率显著高于对照小鼠。此外，以前的寨卡病毒感染增强了对西尼罗河病毒的体液免疫反应。这些发现可能与寨卡病毒和西尼罗河病毒共同传播的地理区域有关，也可能与未来开发广谱黄病毒疫苗有关。
Flaviviruses are RNA viruses that constitute a worrisome threat to global human and animal health. Zika virus (ZIKV), which was initially reported to cause a mild disease, recently spread in the Americas, infecting millions of people. During this recent epidemic, ZIKV infection has been linked to serious neurological diseases and birth defects, specifically Guillain-Barrè syndrome (GBS) and microcephaly. Because information about ZIKV immunity remains scarce, we assessed the humoral response of immunocompetent mice to infection with three viral strains of diverse geographical origin (Africa, Asia and America). No infected animals showed any sign of disease or died after infection. However, specific neutralizing antibodies were elicited in all infected mice. Considering the rapid expansion of ZIKV throughout the American continent and its co-circulation with other medically relevant flaviviruses, such as West Nile virus (WNV), the induction of protective immunity between ZIKV and WNV was analyzed. Remarkably, protection after challenge with WNV was observed in mice previously infected with ZIKV, as survival rates were significantly higher than in control mice. Moreover, previous ZIKV infection enhanced the humoral immune response against WNV. These findings may be relevant in geographical areas where both ZIKV and WNV co-circulate, as well as for the future development of broad-spectrum flavivirus vaccines.
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影响因子：
2.3
作者：
Gray TJ;Webb CE
通讯作者：
Webb CE
影响因子：
3.8
作者：
Dowall SD;Graham VA;Rayner E;Atkinson B;Hall G;Watson RJ;Bosworth A;Bonney LC;Kitchen S;Hewson R
通讯作者：
Hewson R
影响因子：
30.5
作者：
Dejnirattisai W;Supasa P;Wongwiwat W;Rouvinski A;Barba-Spaeth G;Duangchinda T;Sakuntabhai A;Cao-Lormeau VM;Malasit P;Rey FA;Mongkolsapaya J;Screaton GR
通讯作者：
Screaton GR
影响因子：
8.8
作者：
Dowd KA;DeMaso CR;Pelc RS;Speer SD;Smith ARY;Goo L;Platt DJ;Mascola JR;Graham BS;Mulligan MJ;Diamond MS;Ledgerwood JE;Pierson TC
通讯作者：
Pierson TC
DOI：
10.1126/science.aah6157
发表时间：
2016-09-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Abbink P;Larocca RA;De La Barrera RA;Bricault CA;Moseley ET;Boyd M;Kirilova M;Li Z;Ng'ang'a D;Nanayakkara O;Nityanandam R;Mercado NB;Borducchi EN;Agarwal A;Brinkman AL;Cabral C;Chandrashekar A;Giglio PB;Jetton D;Jimenez J;Lee BC;Mojta S;Molloy K;Shetty M;Neubauer GH;Stephenson KE;Peron JP;Zanotto PM;Misamore J;Finneyfrock B;Lewis MG;Alter G;Modjarrad K;Jarman RG;Eckels KH;Michael NL;Thomas SJ;Barouch DH
通讯作者：
Barouch DH