ELEVATED CONCENTRATIONS OF THE BETA-SUBUNIT OF HUMAN CHORIONIC-GONADOTROPIN AND TESTOSTERONE IN THE AMNIOTIC-FLUID OF GESTATIONS OF DIABETIC MOTHERS
ELEVATED CONCENTRATIONS OF THE BETA-SUBUNIT OF HUMAN CHORIONIC-GONADOTROPIN AND TESTOSTERONE IN THE AMNIOTIC-FLUID OF GESTATIONS OF DIABETIC MOTHERS
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DOI：
10.1016/0002-9378(86)90746-5
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发表时间：
1986-05-01
影响因子：
9.8
通讯作者：
RYAN, KJ
中科院分区：
文献类型：
--
作者：
BARBIERI, RL;SALTZMAN, DH;RYAN, KJ
睾丸间质细胞和卵巢卵泡膜黄体细胞增生是糖尿病母亲的婴儿常见的组织学发现。通过测量β-淀粉样蛋白来研究该组织学发现的功能相关性。糖尿病母亲（N = 34）和对照组妇女（N = 34）妊娠期羊水室中人绒毛膜促性腺激素亚基、睾酮、双氢睾酮、雄烯二酮、雌二醇和雌酮。当与对照受试者的妊娠相比时，糖尿病母亲的妊娠具有显著更高的β-人绒毛膜促性腺激素亚单位。妊娠期无论是男性或女性胎儿的糖尿病母亲有显着较高的羊水睾酮和双氢睾酮水平相比，他们的前瞻性性别对照。在糖尿病母亲的男性胎儿妊娠中，β-人绒毛膜促性腺激素和睾酮亚基。糖尿病母亲和对照组孕妇的羊水雄烯二酮、雌二醇或雌酮水平无显著差异。这些结果表明，在糖尿病母亲的婴儿中观察到的睾丸间质细胞和卵巢卵泡膜-黄体细胞增生部分是由于人绒毛膜促性腺激素水平升高，并与羊水中睾酮和双氢睾酮浓度升高有关。
Hyperplasia of testicular Leydig cells and ovarian theca-lutein cells is a common histologic finding in infants of diabetic mothers. The functional correlates of this histologic finding were investigated by measurement of the .beta.-subunit of human chorionic gonadotropin, testosterone, dihydrotestosterone, androstenedione, estradiol, and estrone in the amniotic fluid compartment of gestations with male and female fetuses in diabetic mothers (N = 34) and control women (N = 34) at term. When compared with those of control subjects, gestations of diabetic mothers had significantly higher amniotic fluid concentrations of the .beta.-subunit of human chorionic gonadotropin. Gestations with either male or female fetuses in diabetic mothers had significantly higher amniotic fluid testosterone and dihydrotestosterone levels when compared with those of their rspective gender controls. In gestations with male fetuses in diabetic mothers there was a significant positive correlation between the .beta.-subunit of human chorionic gonadotropin and testosterone. There was no significant difference in amniotic fluid androstenedione, estradiol, or estrone levels between the gestations of diabetic mothers and those of control women. These results suggest that the testicular Leydig cell and ovarian theca-lutein cell hyperplasia seen in infants of diabetic mothers is due, in part, to elevated levels of human chorionic gonadotropin and is associated with elevated testosterone and dihydrotestosterone concentrations in the the amniotic fluid.