Value of morphometry as an independent prognostic factor in renal cell carcinoma.
Value of morphometry as an independent prognostic factor in renal cell carcinoma.
复制标题
形态测量作为肾细胞癌独立预后因素的价值。
作者：
J. Ruíz;M. Hernandez;J. Martínez;C. Vera;J. Jiménez
对159例肾腺癌进行了细胞核形态计量学研究。计算了面积、周长、长轴、短轴和形状因子等核参数的平均值和标准偏差。中位生存期为72个月，5年、10年和15年累积生存率分别为50%、42%和33%。除形状因子外，形态参数的取值均呈随阶段增加的趋势。核面积是预测生存时间变异性的最佳参数。对各分期进行Cox回归模型分析，探讨其与生存期长短的关系。对于T1-2N0M0期，核面积是唯一被选为预后独立显著预测因子的变量。对于其余的阶段，没有变量被选为任何显著水平的预测因子。
Nuclear morphometry was performed in 159 adenocarcinomas of the kidney. The mean and SD of the following nuclear parameters were calculated: area, perimeter, major axis, minor axis and a shape factor. Median survival, including all stages, was 72 months and cumulative survival at 5, 10 and 15 years of 50, 42 and 33%, respectively. Values of morphometric parameters, except for shape factor, tend to increase in proportion to stage. Nuclear area was the best parameter to predict the variability in survival time. The Cox regression model was performed for each stage, and the relationship with length of survival time was studied. For stage T1-2 N0 M0, nuclear area was the only variable chosen as an independent significant predictor of outcome. For the rest of the stages, no variables were selected as predictors at any significant level.