Nanomicellar formulations for sustained drug delivery: strategies and underlying principles.
Nanomicellar formulations for sustained drug delivery: strategies and underlying principles.
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DOI：
10.2217/nnm.10.10
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Kompella UB
中科院分区：
文献类型：
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作者：
Trivedi R;Kompella UB
小于 100 nm 的胶束递送系统可以很容易地制备。虽然胶束可以深入组织渗透以实现靶向药物输送，但它们通常会在体内迅速分解。因此，胶束纳米载体的持续药物递送是一个挑战。本文总结了使用胶束纳米载体持续药物递送的各种关键策略和基本原理。与其他竞争性递送系统（例如聚合物微粒和纳米颗粒）进行了比较。两亲性分子在适当的液体介质中自组装形成纳米级胶束。缓释纳米胶束载体的策略包括使用前药、药物聚合物缀合物、具有低临界胶束浓度或具有反向热响应性质的新型聚合物、反向胶束、逐层组装的多层胶束、能够在体内形成胶束的聚合物膜以及固体支持物上的胶束涂层。这些新的胶束系统有望实现持续的药物输送。
Micellar delivery systems smaller than 100 nm can be readily prepared. While micelles allow a great depth of tissue penetration for targeted drug delivery, they usually disintegrate rapidly in the body. Thus, sustained drug delivery from micellar nanocarriers is a challenge. This article summarizes various key strategies and underlying principles for sustained drug delivery using micellar nanocarriers. Comparisons are made with other competing delivery systems such as polymeric microparticles and nanoparticles. Amphiphilic molecules self-assemble in appropriate liquid media to form nanoscale micelles. Strategies for sustained release nanomicellar carriers include use of prodrugs, drug polymer conjugates, novel polymers with low critical micellar concentration or of a reverse thermoresponsive nature, reverse micelles, multi-layer micelles with layer by layer assembly, polymeric films capable of forming micelles in vivo and micelle coats on a solid support. These new micellar systems are promising for sustained drug delivery.